TY - T1的家里开始长期高强度无创通气在慢性阻塞性肺病慢性hypercapnic呼吸衰竭患者:考虑试验JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.国会2019欧元。RCT451六世- 54 - 5 63 SP - RCT451盟Duiverman Marieke l . AU -膀胱Gerrie盟——Vonk Judith m . AU - Van Boven工作F.M.盟——Nieuwenhuis Jellie盟——Hazenberg安达盟——Kerstjens Huib点非盟- Wijkstra,彼得·J Y1 - 2019/09/28 UR - //www.qdcxjkg.com/content/54/suppl_63/RCT451.abstract N2 -背景:慢性高强度无创通气(NIV)已成为稳定hypercapnic循证护理慢性阻塞性肺疾病(COPD)患者。由于患者的数量正在增加,家庭开始和合将大大减轻医疗负担。假设:家庭开始慢性高强度和合hypercapnic稳定COPD住院启动非劣。方法:六十七例稳定hypercapnic COPD患者随机标准住院和合起始或家庭之间和合起始使用远程医疗。主要结果是白天动脉二氧化碳压力(PaCO2)减少5 6个月后,non-inferiority距0.4 kPa。次要结果(HRQoL)健康相关的生活质量和成本。结果:家里和合起始非劣是住院起始(调整后的平均差PaCO2改变家里与住院6个月:0.04 kPa (95% CI -0.3 - 0.4),两组显示减少PaCO2在6个月相比,基线(:从7.3±0.9,6.4±0.8 kPa(术中,0.001);住院:从7.4±1.0,6.4±0.6 kPa(术中;0.001))。在改善HRQoL没有差别(慢性阻塞性肺病的临床问卷总分:调整后的平均差0.0 (95% CI -0.4 - 0.5))。 Furthermore, home NIV initiation was significantly cheaper (home: median €3768 (IQR €3546-€4163) vs. hospital: median €8537 (IQR €7540-€9175); P<0.001).Discussion: This is the first study showing that home initiation of high-intensity NIV in stable hypercapnic COPD patients is non-inferior to to in-hospital initiation, with over 50% savings of costs.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, RCT451.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -