TY - T1的右心室lusitropy受损与通气效率低下在肺动脉高血压JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.00342 -2019欧元六世- 54 - 5 SP - 1900342 AU Tello Khodr AU - Dalmer,安东尼娅AU - Vanderpool,丽贝卡盟——Ghofrani·侯赛因·a . AU - NaeijeRobert AU - Roller, Fritz AU - Seeger, Werner AU - Dumitrescu, Daniel AU - Sommer, Natascha AU - Brunst, Anne AU - Gall, Henning AU - Richter，N2 -心肺运动试验(Cardiopulmonary exercise test, CPET)是评估肺动脉高压(pulmonary arterial hypertension, PAH)患者功能容量和预后的重要工具。然而，CPET参数与右心室(RV)功能适应后负荷的关系仍不完全清楚。本研究中，对37例PAH患者(31例特发性)进行单跳压力-容积环路测量右心室收缩期末弹性(Ees)、动脉弹性(Ea)和舒张期弹性(Eed)。通过磁共振成像评估肺动脉硬度。结果与CPET变量相关。使用logistic回归分析评价右心室功能参数对临床相关通气不足的预测相关性，定义为分钟通气/二氧化碳产量(V 'E /V 'CO2)斜率>48。V 'E /V 'CO2斜率的中位数(四分位数范围)为42 (32-52)，V 'E /V 'CO2最低点为40(31-44)。峰值潮末二氧化碳张力(PETCO2)的平均值±标准差为23±8 mmHg。Ea、ed和反映肺动脉刚度的参数(电容和膨胀)与V 'E /V 'CO2斜率、V 'E /V 'CO2最低点、PETCO2和峰值氧脉冲相关。 RV Ees and RV–arterial coupling as assessed by the Ees/Ea ratio showed no correlations with CPET parameters. Ea (univariate OR 7.28, 95% CI 1.20–44.04) and Eed (univariate OR 2.21, 95% CI 0.93–5.26) were significantly associated with ventilatory inefficiency (p<0.10).Our data suggest that impaired RV lusitropy and increased afterload are associated with ventilatory inefficiency in PAH.Right ventricular diastolic stiffness and afterload (pressure–volume loop measurement) are associated with ventilatory inefficiency during exercise and may contribute to dyspnoea via increased chemosensitivity in pulmonary arterial hypertension http://bit.ly/30lLy9t ER -