TY - T1的右心室lusitropy受损与通气效率低下在肺动脉高血压JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.00342 -2019欧元六世- 54 - 5 SP - 1900342 AU Tello Khodr AU - Dalmer,安东尼娅AU - Vanderpool,丽贝卡盟——Ghofrani·侯赛因·a . AU - Naeije罗伯特·AU - Roller，弗里茨·AU - Seeger，维尔纳·AU - Dumitrescu，丹尼尔·AU - Sommer，娜塔莎·AU - Brunst，安妮·AU - Gall，亨宁·AU - Richter，Manuel J. Y1 - 2019/11/01 UR - //www.qdcxjkg.com/content/54/5/1900342.abstract N2 -心肺运动试验(CPET)是评估肺动脉高压(PAH)患者功能能力和预后的重要工具。然而，CPET参数与右心室(RV)功能适应后负荷的关系尚不完全清楚。在本研究中，37例PAH患者(其中31例特发性)进行了单搏压-容量环路测量右心室收缩期末弹性(Ees)、动脉弹性(Ea)和舒张期弹性(Eed)。通过磁共振成像评估肺动脉硬度。结果与CPET变量相关。使用logistic回归分析评估右心室功能参数与临床相关呼吸无效(定义为分钟通气/二氧化碳生产(V 'E /V 'CO2)斜率>48)的预测相关性。V 'E /V 'CO2斜率中位(四分位差)为42 (32-52)，V 'E /V 'CO2最低点为40(31-44)。呼气末二氧化碳压力峰值(PETCO2)的平均±sd为23±8 mmHg。Ea、Eed和反映肺动脉硬度(电容和扩张性)的参数与V 'E /V 'CO2斜率、V 'E /V 'CO2最低点、PETCO2和氧脉冲峰值相关。 RV Ees and RV–arterial coupling as assessed by the Ees/Ea ratio showed no correlations with CPET parameters. Ea (univariate OR 7.28, 95% CI 1.20–44.04) and Eed (univariate OR 2.21, 95% CI 0.93–5.26) were significantly associated with ventilatory inefficiency (p<0.10).Our data suggest that impaired RV lusitropy and increased afterload are associated with ventilatory inefficiency in PAH.Right ventricular diastolic stiffness and afterload (pressure–volume loop measurement) are associated with ventilatory inefficiency during exercise and may contribute to dyspnoea via increased chemosensitivity in pulmonary arterial hypertension http://bit.ly/30lLy9t ER -