PT - JOURNAL ARTICLE AU - Krishna, Mamidipudi Thirumala AU - Subramanian, Anuradhaa AU - Adderley, Nicola J. AU - Zemedikun, Dawit T. AU - Gkoutos, Georgios V. AU - Nirantharakumar, Krishnarajah TI过敏性疾病和自身免疫疾病的长期风险:纵向队列研究和聚类分析援助- 10.1183/13993003.00476 -2019 DP - 2019年11月01 TA -欧洲呼吸杂志》第六PG - 1900476 - 54 IP - 5 4099 - //www.qdcxjkg.com/content/54/5/1900476.short 4100 - //www.qdcxjkg.com/content/54/5/1900476.full所以欧元和J2019 11月01;过敏性疾病和自身免疫性疾病之间的关系尚不明确。我们的目的是确定自身免疫性疾病在变应性鼻炎/结膜炎(ARC)、特应性湿疹和哮喘中的发病率，并调查其共发生模式。这是一项回顾性队列研究(1990-2018)，使用的数据提取自健康改善网络(英国初级保健数据库)。暴露组包括ARC、特应性湿疹和哮喘(所有年龄)。对于每个暴露的患者，使用了两个随机选择的年龄和性别匹配的对照，没有记录过敏疾病。采用泊松回归计算校正发病率比(aIRRs)。横断面研究也采用关联规则挖掘(ARM)来调查疾病聚集。结果共纳入ARC患者782 320例、特应性湿疹患者1 393 570例、哮喘患者1 049 868例。与对照组相比，三种过敏性疾病中系统性红斑狼疮(SLE)、Sjögren’s综合征、白癜风、类风湿关节炎、银屑病、恶性贫血、炎症性肠病、乳糜泻和自身免疫性甲状腺炎的aIRRs均较高。其中，ARC中SLE(1.45)和Sjögren’s综合征(1.88)的aIRRs较高; aIRRs of SLE (1.44), Sjögren's syndrome (1.61) and myasthenia (1.56) were higher in asthma; and aIRRs of SLE (1.86), Sjögren's syndrome (1.48), vitiligo (1.54) and psoriasis (2.41) were higher in atopic eczema. There was no significant effect of the three allergic diseases on multiple sclerosis or of ARC and atopic eczema on myasthenia. Using ARM, allergic diseases clustered with multiple autoimmune disorders. Three age- and sex-related clusters were identified, with a relatively complex pattern in females ≥55 years old.Conclusions The long-term risks of autoimmune disorders are significantly higher in patients with allergic diseases. Allergic diseases and autoimmune disorders show age- and sex-related clustering patterns.This study has shown that the long-term risk of autoimmune disorders is significantly higher in patients with allergic diseases. Allergic diseases and autoimmune disorders co-occur, and show an age- and sex-related clustering pattern. http://bit.ly/33tqkZn