@article {Krishna1900476, author = Krishna, Mamidipudi Thirumala and Subramanian, Anuradhaa and Adderley, Nicola J. and Zemedikun, Dawit T. and Gkoutos, Georgios V. and Nirantharakumar, Krishnarajah}， title ={过敏性疾病和自身免疫性疾病的长期风险:(1)过敏性疾病与自身免疫性疾病之间的关系尚未得到很好的证实。188bet官网地址我们的目的是确定变应性鼻炎/结膜炎(ARC)、特应性湿疹和哮喘中自身免疫性疾病的发病率，并研究其共存模式。方法:这是一项回顾性队列研究(1990年，2018年)，使用从健康改善网络(英国初级保健数据库)提取的数据。暴露组包括ARC、特应性湿疹和哮喘(所有年龄)。对于每个暴露的患者，随机选择两名年龄和性别匹配、没有过敏疾病记录的对照组。采用泊松回归计算调整后的发病率比(aIRRs)。采用关联规则挖掘(ARM)进行横断面研究，调查疾病群集。结果共纳入ARC患者782 320例，特应性湿疹患者1 393 570例，哮喘患者1 049 868例。三种变应性疾病中系统性红斑狼疮(SLE)、干燥综合征、白癜风、类风湿关节炎、银屑病、恶性贫血、炎症性肠病、腹腔疾病和自身免疫性甲状腺炎的aIRRs均高于对照组。具体而言，SLE(1.45)和干燥综合征(1.88)的airr在ARC中较高;SLE(1.44)、干燥综合征(1.61)和肌无力(1.56)在哮喘组较高; and aIRRs of SLE (1.86), Sj{\"o}gren{\textquoteright}s syndrome (1.48), vitiligo (1.54) and psoriasis (2.41) were higher in atopic eczema. There was no significant effect of the three allergic diseases on multiple sclerosis or of ARC and atopic eczema on myasthenia. Using ARM, allergic diseases clustered with multiple autoimmune disorders. Three age- and sex-related clusters were identified, with a relatively complex pattern in females >=55 years old.Conclusions The long-term risks of autoimmune disorders are significantly higher in patients with allergic diseases. Allergic diseases and autoimmune disorders show age- and sex-related clustering patterns.This study has shown that the long-term risk of autoimmune disorders is significantly higher in patients with allergic diseases. Allergic diseases and autoimmune disorders co-occur, and show an age- and sex-related clustering pattern. http://bit.ly/33tqkZn}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/54/5/1900476}, eprint = {//www.qdcxjkg.com/content/54/5/1900476.full.pdf}, journal = {European Respiratory Journal} }