@article {Lenferink1802134，笔者= {Lenferink，安科和van der Palen，工作和van der Valk酒店，保罗D.L.P.M.和Cafarella，保罗和面包车维恩，Anneke和奎恩，斯蒂芬和Groothuis - 奥茨胡恩，凯瑟琳娜G.M。和伯特，莫顿湾和年轻，玛丽和弗里斯，彼得·A和艾芬，塔尼娅W.}，标题= {动作加重COPD患者和合并症计划：一项随机对照试验}，体积= {} 54，数= {5}，elocation-ID = {1802134}，年= {} 2019，DOI = {10.1183 / 13993003.02134-2018}，出版商= {欧洲呼吸学会}，抽象= 188bet官网地址{这个国际随机对照试验评估是否COPD患者合并症，在使用患者定制多疾病恶化的行动计划的训练，有COPD恶化天，比常规护理更少（UC）.COPD患者（慢性阻塞性肺疾病（GOLD）分类II {\ textendash} IV全球倡议）具有> = 1合并症（缺血性心脏疾病，心脏衰竭，糖尿病，焦虑症，抑郁症）被随机分配到患者定制的自管理干预组（n = 102）或UC（N = 99）。每日症状日记已经完成了12个月。主要结果{\ textquotedblleft}每人每年患者{\ textquotedblright} COPD急性加重天使用意向性治疗中的每患有COPD恶化天每年（自我管理的数量，观察analyses.No显著差异进行评估：中位数9.6（四分位数间距（IQR）0.7 {\ textendash} 31.1）; UC：中值15.6（IQR 3.0 {\ textendash} 40.3）;发病率比（IRR）0.87（95 \％CI 0.54; 1.39）; p = 0.546）。有每COPD恶化一个显著较短的持续时间的自我管理（自我管理：中位数8.1（IQR 4.8 {\ textendash} 10.1）天; UC：中值9.5（IQR 7.0 {\ textendash} 15.1）天; P = 0.021）, with no between-group differences in the total number of respiratory hospitalisations (IRR 0.76 (95\% CI 0.42; 1.35); p=0.348), but a lower probability of >=1 for respiratory-related hospitalisation compared to UC (relative risk 0.55 (95\% CI 0.35; 0.87); p=0.008). No between-group differences were observed in all-cause hospitalisations (IRR 1.07 (95\% CI 0.66; 1.72)) or mortality (self-management: n=4 (3.9\%); UC: n=7 (7.1\%); relative risk 0.55 (95\% CI 0.17; 1.84)).Patient-tailored exacerbation action plans for COPD patients with comorbidities did not significantly reduce exacerbation days, but reduced the duration per COPD exacerbation and the risk of having at least one respiratory-related hospitalisation during follow-up, without excess all-cause mortality.Patient-tailored exacerbation action plans for COPD patients with comorbidities do not reduce exacerbation days, but reduce exacerbation duration and risk of having at least one respiratory-related hospitalisation during follow-up, without excess mortality http://bit.ly/2Mi8Fhc}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/54/5/1802134}, eprint = {//www.qdcxjkg.com/content/54/5/1802134.full.pdf}, journal = {European Respiratory Journal} }