慢性阻塞性肺疾病合并支气管扩张患者气道形态测量:视图在所有气道代JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.02166 -2018欧元六世- 54 - 5 SP - 1802166 AU Everaerts斯蒂芬妮AU -麦克唐纳,约翰·e . AU - Verleden Stijn e . AU -约西波维奇伊凡AU -布恩,马修AU - Dubbeldam,阿德里亚娜盟——Mathyssen Carolien AU - Serre,中盟——杜邦,列文J . AU - Gayan-Ramirez Ghislaine AU - Verschakelen,约翰尼AU -豪格,James c . AU - Verleden基尔特•m . AU - Vanaudenaerde巴特·m . AU -詹森【摘要】N2 -慢性阻塞性肺疾病(COPD)支气管扩张的病理生理过程尚不清楚。在慢性阻塞性肺病中，大大小小的气道逐渐丧失。目前尚不清楚COPD和支气管扩张患者的不同气道世代在多大程度上受到影响。将有支气管扩张的COPD肺外植体与无支气管扩张的COPD肺外植体和未使用的供体肺作为对照。为了研究所有气道世代，使用不同分辨率的多模态成像方法。每组5个肺被冻结(n=15)，并进行计算机断层成像(CT)以评估大气道，每个肺成像4个组织核以测量晚期细支气管。每组增加2个肺(n=6)风干，以获得大叶微ct图像，从而实现气道分割和完整气道树的三维量化。与无支气管扩张的COPD肺相比，有支气管扩张的COPD肺气道明显增多(p<0.001)，气道数目与对照组肺相似。 This difference was present in both upper and lower lobes. Lack of tapering was present (p=0.010) and larger diameters were demonstrated in lower lobes with bronchiectasis (p=0.010). MicroCT analysis of tissue cores showed similar reductions of tissue percentage, surface density and number of terminal bronchioles in both COPD groups compared to control lungs.Although terminal bronchioles were equally reduced in COPD lungs with and without bronchiectasis, significantly more large and small airways were found in COPD lungs with bronchiectasis.Although terminal bronchioles are equally reduced in COPD lungs with and without bronchiectasis, significantly more large and small airways are found in COPD lungs with bronchiectasis http://bit.ly/2YJ5kKs ER -