% 0期刊文章% Everaerts,斯蒂芬妮·麦克唐纳%,约翰·e·% Verleden, Stijn e . %约西波维奇伊凡%布恩,马修% Dubbeldam,阿德里亚娜% Mathyssen, Carolien % Serre,杰夫%)杜邦,列文Gayan-Ramirez j . %, Ghislaine % Verschakelen,约翰尼%豪格,James c . % Verleden,基尔特•m . % Vanaudenaerde,巴特,m . %詹森Wim % T气道形态测量学与支气管扩张:慢性阻塞性肺病欧洲呼吸杂志%P 1802166v 54 %N 5% X目前还不清楚慢性阻塞性肺病(COPD)支气管扩张的病理生理过程。在慢性阻塞性肺病中，大大小小的气道逐渐丧失。目前尚不清楚COPD和支气管扩张患者的不同气道世代在多大程度上受到影响。将有支气管扩张的COPD肺外植体与无支气管扩张的COPD肺外植体和未使用的供体肺作为对照。为了研究所有气道世代，使用不同分辨率的多模态成像方法。每组5个肺被冻结(n=15)，并进行计算机断层成像(CT)以评估大气道，每个肺成像4个组织核以测量晚期细支气管。每组增加2个肺(n=6)风干，以获得大叶微ct图像，从而实现气道分割和完整气道树的三维量化。与无支气管扩张的COPD肺相比，有支气管扩张的COPD肺气道明显增多(p<0.001)，气道数目与对照组肺相似。这种差异在上叶和下叶都存在。支气管扩张患者的下肺叶直径增大(p=0.010)，但未见逐渐变细(p=0.010)。 MicroCT analysis of tissue cores showed similar reductions of tissue percentage, surface density and number of terminal bronchioles in both COPD groups compared to control lungs.Although terminal bronchioles were equally reduced in COPD lungs with and without bronchiectasis, significantly more large and small airways were found in COPD lungs with bronchiectasis.Although terminal bronchioles are equally reduced in COPD lungs with and without bronchiectasis, significantly more large and small airways are found in COPD lungs with bronchiectasis http://bit.ly/2YJ5kKs %U //www.qdcxjkg.com/content/erj/54/5/1802166.full.pdf