@article {Everaerts1802166，作者= {Everaerts，斯蒂芬妮和麦克唐纳，约翰E.和Verleden，斯泰恩E.和约西波维奇，IV {\ '一} n和布恩，马修和Dubbeldam，Adriana和Mathyssen，Carolien和塞尔{\'ë}，杰夫和杜邦，利芬J.和加扬-拉米雷斯，吉莱纳和Verschakelen，约翰尼拉和霍格，詹姆斯C.和Verleden，吉尔特M.和Vanaudenaerde，巴特M.和詹森，维姆}，标题= {气道形态中COPD支气管扩张：对所有气道世代的视图}，体积= {54}，数= {5}，elocation-ID = {1802166}，年= {2019}，DOI = {10.1183 / 13993003.02166-2018}，出版商={188bet官网地址欧洲呼吸协会}，抽象= {在慢性阻塞性肺疾病（COPD）底层支气管扩张的病理生理学过程不被理解。在慢性阻塞性肺病，小型和大型航空公司正在逐渐丧失。它目前还不知道到什么程度的COPD患者和支气管扩张不同的气道几代人involved.COPD植肺支气管扩张进行了比较，COPD植肺支气管扩张没有和未使用的供体肺作为对照。为了调查所有气道代，采用不同分辨率的多模成像方法被进行。每组五个肺冷冻（N = 15）和大气道评估后行计算机断层扫描（CT）成像，以用于成像终末细支气管的测量每个肺4个组织核心。每组两个额外的肺（N = 6）为大叶性肺炎显微CT图像，其允许相对于COPD肺而不支气管扩张（对气道分割和支气管扩张的气道完全tree.COPD肺的三维量化有显著更呼吸道风干\<0.001），具有类似于控制肺大气道号码。这种差异存在于两个上部和下部凸角。缺乏锥形的存在（p值= 0.010）和较大直径与支气管扩张（p值= 0.010）下叶进行了论证。 MicroCT analysis of tissue cores showed similar reductions of tissue percentage, surface density and number of terminal bronchioles in both COPD groups compared to control lungs.Although terminal bronchioles were equally reduced in COPD lungs with and without bronchiectasis, significantly more large and small airways were found in COPD lungs with bronchiectasis.Although terminal bronchioles are equally reduced in COPD lungs with and without bronchiectasis, significantly more large and small airways are found in COPD lungs with bronchiectasis http://bit.ly/2YJ5kKs}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/54/5/1802166}, eprint = {//www.qdcxjkg.com/content/54/5/1802166.full.pdf}, journal = {European Respiratory Journal} }