ty - jour t1 - 户外空气污染和童年哮喘的负担跨越欧洲jf - 欧洲呼吸杂志jo - 欧元reshir j do - 10.1183 / 13993003.02194-2018 vl - 54是 - 4 sp - 1802194 Au - khreis，haneen au - cirach，Marta Au - Mueller，Natalie Au - De Hoogh，Kees Au - Hoek，Gerard Au - Nieuwenhuijsen，Mark J. Au - Rojas-Rueda，David Y1 - 2019/10 / 01 UR - //www.qdcxjkg.com/ Content/54/4/1802194.Abstract N2 - 背景新兴的证据表明，空气污染可能有助于儿童哮喘发育。我们估计了欧洲常规氮二氧化氮（NO2），颗粒物质≤2.5μm（PM2.5）和黑碳（BC）的颗粒物质≤2.5μm的患者哮喘的负担。我们组合国家级儿童发病率并汇集了童年（年龄1-14岁）人口计数的曝光措施，并且在1欧欧洲国家的1 540 386 1 km×1km×1km×1 km×1 km细胞的曝光估计。年平均污染物浓度从经过验证和协调的欧洲土地利用回归模型获得。我们调查了两种曝光减少方案。首先，我们使用了建议的年度世界卫生组织（WHO）空气质量指南价值。第二，我们使用底层间分析中41项研究中记录的最小空气污染水平。结果NO2从1.4到70.0μg·m-3的范围，平均为11.8μg·m-3。PM2.5范围为2.0至41.1μg·m-3，平均为11.6μg·m-3。BC范围从0.003到3.7×10-5 m-1，平均为1.0×10-5 m-1。遵守NO2和PM2.5估计谁指导方针分别预防2434（0.4％）和66个567（11％）事件案件。 Meeting the minimum air pollution levels for NO2 (1.5 µg·m−3), PM2.5 (0.4 µg·m−3) and BC (0.4×10−5 m−1) was estimated to prevent 135 257 (23%), 191 883 (33%) and 89 191 (15%) incident cases, respectively.Conclusions A significant proportion of childhood asthma cases may be attributable to outdoor air pollution and these cases could be prevented. Our estimates underline an urgent need to reduce children's exposure to air pollution.A significant proportion (up to 33%) of incident childhood asthma cases across Europe may be attributable to outdoor air pollution. These cases are largely preventable, underlying an urgent need to reduce children's exposure to NO2, PM2.5 and black carbon. http://bit.ly/36Fe5KN ER -