RT期刊文章SR电子T1射线在吸烟者肺容积预测发展为慢性阻塞性肺病保留肺量测定法在SPIROMICS摩根富林明欧洲呼吸杂志乔和J FD欧元欧洲呼吸学会SP 1802214 10.1183/13993003.02214 -2018签证官54是4 A1 Arjomandi人士曾A1,泗阳A1 Barjaktarevic, Igor A1巴尔,r·格雷厄姆A1布,尤金·r·A1圆顶礼帽188bet官网地址,拉塞尔•A1布,拉塞尔·g·A1。克里内,杰拉德J . A1考米拉Alejandro A1库珀克里斯托弗·b·A1库珀,David j . A1柯蒂斯,Jeffrey l . A1 Dransfield,马克·t·A1汉美兰k A1汉斯,Nadia n A1霍夫曼,埃里克·a . A1 Kaner Robert j . A1 Kanner,理查德·e·A1 Krishnan,杰瑞·a . A1潘恩,罗伯特•彼得斯A1 (Stephen p . A1雷纳德,斯蒂芬。A1半圆,没有肺气流阻塞的吸烟者预测进展为明显的慢性阻塞性肺病(COPD)的特征尚不明确。我们对849名现役和已戒烟者(≥20包岁)进行了一项事后分析，采用来自COPD研究(SPIROMICS)人群的保留肺活量测定法和中间结果测量法，这些人群接受了肺的基线CT扫描和连续肺活量测定法。我们用混合效应线性模型检验了ct衍生的肺活量(代表空气滞留)是否可以预测不良的呼吸结果和明显的慢性阻塞性肺病肺量的快速下降。在这些1秒用力呼气容积(FEV1)与用力肺活量(FVC)比值正常的受试者中，ct测量的剩余容积(RVCT)与总肺活量(TLCCT)比值差异很大，从21%到59%不等。在2.5±0.7年的随访中，RVCT/TLCCT较高的受试者FEV1/FVC下降的差异更大;无论人口统计、基线肺量测定、呼吸症状评分、吸烟状况(以前与现在)或吸烟负担(包年)如何，RVCT/TLCCT上三分位组每年的下降速度比下三分位组(p=0.015)快0.66% (95% CI 0.06%-1.27%)。因此，RVCT/TLCCT较高的受试者在上、下RVCT/TLCCT三分位中更有可能发展成肺量性慢性阻塞性肺病(或5.7 (95% CI 2.4-13.2));p < 0.001)。 Other CT indices of air trapping showed similar patterns of association with lung function decline; however, when all CT indices of air trapping, emphysema, and airway disease were included in the same model, only RVCT/TLCCT retained its significance.Increased air trapping based on radiographic lung volumes predicts accelerated spirometry decline and progression to COPD in smokers without obstruction.Radiographic lung volumes and related computed tomography measures that represent air trapping are associated with an accelerated decline in lung function and can identify susceptible smokers at increased risk of progressing to overt COPD http://bit.ly/32QqiKQ