TY - JOUR T1 -意大利米兰寻求庇护者中的结核病:流行病学分析和评价干预措施的JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.00896 -2019欧元六世- 54 - 4 SP - 1900896 AU -别墅,西蒙盟——Codecasa Luigi Ruffo AU - Faccini,马里诺盟——Pontello董事长米莱拉•玛丽亚AU - Ferrarese Maurizio盟——Castellotti Paola弗朗西斯卡盟——Senatore塞布丽娜盟——该行安娜盟——Mazzola酯非盟- Perno,卡洛费德里科•盟——Campisi Daniela盟——Saporiti Matteo AU - Raviglione,马里奥·卡洛Y1 - 2019/10/01 UR - //www.qdcxjkg.com/content/54/4/1900896.abstract N2 -在欧盟国家,结核病(TB)主要影响被边缘化的人,包括寻求庇护者。截至2017年，从高发病率国家流向意大利的移民人数有所增加，给国家卫生系统带来了挑战。本研究旨在评估2016-2017两年期期间米兰寻求庇护者中的结核病和潜伏结核病感染(LTBI)患病率，并评估实施的干预措施。开发了结核病和LTBI两级主动监测和筛查系统。寻求庇护者在接收地点通过结核菌素皮肤试验(TST)和问卷进行了初步筛查。在区域结核病参考中心，阳性结果的患者接受了胸部x光检查。年龄35岁胸部x线片阴性的人进一步采用干扰素-γ释放试验进行检测。如果检测结果为阳性，则给予LTBI处理。将结核病和LTBI患病率与文献资料进行比较。A total of 5324 asylum seekers, mostly young (10–39 years; 98%), male (84%) and from sub-Saharan Africa (69%), were enrolled in the study. 69 active TB cases were diagnosed and 863 LTBI-positive individuals were detected. TB prevalence was high (1236 per 100 000 population) and LTBI prevalence was 28%. Despite losses (41%) during the transition from initial screening sites and the diagnostic centre, a good TB cure rate (84%) and optimal LTBI treatment completion (94%) were achieved.Our study shows that TB incidence is high among asylum seekers in Milan and that well-coordinated screening measures are critical for early diagnosis and treatment. It also proves that rolling out successful at-scale interventions for both prophylaxis and disease management is feasible.Asylum seekers are vulnerable to TB owing to migration-related events and marginalisation in destination countries. Coordinated screening and surveillance programmes using well-informed datasets can reduce TB transmission, improve care and address LTBI. http://bit.ly/2SPp0uZ ER -