TY - T1的肺结核在寻求庇护者我n Milan, Italy: epidemiological analysis and evaluation of interventions JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00896-2019 VL - 54 IS - 4 SP - 1900896 AU - Villa, Simone AU - Codecasa, Luigi Ruffo AU - Faccini, Marino AU - Pontello, Mirella Maria AU - Ferrarese, Maurizio AU - Castellotti, Paola Francesca AU - Senatore, Sabrina AU - Lamberti, Anna AU - Mazzola, Ester AU - Perno, Carlo Federico AU - Campisi, Daniela AU - Saporiti, Matteo AU - Raviglione, Mario Carlo Y1 - 2019/10/01 UR - //www.qdcxjkg.com/content/54/4/1900896.abstract N2 - In countries of the European Union, tuberculosis (TB) mainly affects marginalised people, including asylum seekers. Migratory flows from high-incidence countries to Italy have increased up to 2017, posing challenges to the national health system. This study sought to assess TB and latent TB infection (LTBI) prevalence among asylum seekers in Milan during the biennium 2016–2017 and to evaluate interventions in place.A two-level active surveillance and screening system was developed for both TB and LTBI. Asylum seekers underwent an initial screening with a tuberculin skin test (TST) and a questionnaire at the receiving sites. At the Regional TB Reference Centre, those with a positive result underwent chest radiography. People aged <35 years with negative chest radiography results underwent further testing by interferon-γ release assay. If results of the assay were positive, LTBI treatment was offered. TB and LTBI prevalence were compared with literature data.A total of 5324 asylum seekers, mostly young (10–39 years; 98%), male (84%) and from sub-Saharan Africa (69%), were enrolled in the study. 69 active TB cases were diagnosed and 863 LTBI-positive individuals were detected. TB prevalence was high (1236 per 100 000 population) and LTBI prevalence was 28%. Despite losses (41%) during the transition from initial screening sites and the diagnostic centre, a good TB cure rate (84%) and optimal LTBI treatment completion (94%) were achieved.Our study shows that TB incidence is high among asylum seekers in Milan and that well-coordinated screening measures are critical for early diagnosis and treatment. It also proves that rolling out successful at-scale interventions for both prophylaxis and disease management is feasible.Asylum seekers are vulnerable to TB owing to migration-related events and marginalisation in destination countries. Coordinated screening and surveillance programmes using well-informed datasets can reduce TB transmission, improve care and address LTBI. http://bit.ly/2SPp0uZ ER -