TY - T1的时间趋势诊断检测for primary ciliary dyskinesia in Europe JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00528-2019 VL - 54 IS - 4 SP - 1900528 AU - Halbeisen, Florian S. AU - Shoemark, Amelia AU - Barbato, Angelo AU - Boon, Mieke AU - Carr, Siobhan AU - Crowley, Suzanne AU - Hirst, Rob AU - Karadag, Bulent AU - Koerner-Rettberg, Cordula AU - Loebinger, Michael R. AU - Lucas, Jane S. AU - Maitre, Bernard AU - Mazurek, Henryk AU - Özçelik, Uğur AU - Martinů, Vendula AU - Schwerk, Nicolaus AU - Thouvenin, Guillaume AU - Tschanz, Stefan A. AU - Yiallouros, Panayiotis AU - Goutaki, Myrofora AU - Kuehni, Claudia E. Y1 - 2019/10/01 UR - //www.qdcxjkg.com/content/54/4/1900528.abstract N2 - Despite recent advances in diagnostic methods, diagnosis of primary ciliary dyskinesia (PCD) remains complex. We need a combination of different diagnostic tests, and all have their limitations [1]. In 2009, the first European Respiratory Society (ERS) Task Force on PCD in children published recommendations [2], suggesting that: 1) nasal nitric oxide (nNO) should be measured to screen for PCD in patients aged ≥5 years [3]; and 2) video microscopy (VM) analysis of ciliary beat pattern and frequency [4] plus electron microscopy (EM) [5] should be the key confirmatory diagnostic tests. Genetic testing was not recommended as part of the initial diagnostic testing, but as an additional test for inconclusive cases. The recommended test combination was nNO, VM and EM for patients aged ≥5 years and VM plus EM for younger patients.Adherence to the 2009 ERS task force diagnostic recommendations was low. To further improve PCD diagnosis, we must be more diligent and engaging in implementing the new evidence-based guidelines published in 2017. http://bit.ly/2zvjpBh ER -