RT期刊文章SR电子T1全身性和局部炎症的模式，患有流感JF欧洲呼吸道杂志的哮喘患者JO EUR RESSIR J FD欧洲呼吸社会SP 1900949 DO 10.1183/13993003.00949-2019-2019-2019 vo 54188bet官网地址Jake A1 Tunstall，Tanushree A1 Thwaites，Ryan S. A1 Hoang，Long T. A1马赛克调查员A1 Kon，Onn Min A1 Zambon，Maria C. A1 Hansel，Trevor T. A1 Openshaw，Peter J. Yr 2019 UL HTTP：//www.qdcxjkg.com/content/54/4/1900949.ABSTRACT AB背景患者哮喘患者有流感的住院风险，但是这种倾向的原因是未知的。设定了对PCR确认成人的前瞻性观察性研究在英国11家医院中的流感，测量鼻，鼻咽和全身免疫介质和全血基因表达。133次入院，40％（30％）的哮喘患有哮喘。这些更常见的是女性（70％对38.7％，或3.69，95％CI 1.67–8.18; P = 0.0012），需要更少的机械通气（15％对37.6％，CHI-SCORED 6.78； P = 0.0338），并且更短住院时间（平均8.3对15.3天，p = 0.0333）比没有医院。在没有哮喘的患者中，在给定的皮质类固醇（OR 2.63，95％CI 1.02-6.96; p = 0.0466）或疾病发作后4天（OR 5.49，95％CI 2.28-14.03; P = 4天）中，严重预后更常见。0.0002）。高危人群（包括哮喘）中的流感疫苗接种低于国家政策的预期，抗病毒药药的早期使用不足。组之间的粘膜免疫反应等效。患有哮喘的人具有较高的血清干扰素（IFN）-α，但血清肿瘤坏死因子，白介素（IL）-5，IL-6，CXCL8，CXCL8，CXCL9，IL-10，IL-10，IL-17和CCL2水平（所有P <0.055））； both groups had similar serum IL-13, total IgE, periostin and blood eosinophil gene expression levels. Asthma diagnosis was unrelated to viral load, IFN-α, IFN-γ, IL-5 or IL-13 levels.Conclusions Asthma is common in those hospitalised with influenza, but may not represent classical type 2-driven disease. Those admitted with influenza tend to be female with mild serum inflammatory responses, increased serum IFN-α levels and good clinical outcomes.Patients with asthma hospitalised with influenza are commonly female and lack classical type 2 nasal mucosal inflammation. They have good prognosis with enhanced type 1 interferon production and reduced systemic inflammation. http://bit.ly/2Ovzz7O