@article {Jha1900949作者= {Jha, Akhilesh邓宁,杰克和汤斯顿,Tanushree Thwaites, Ryan s和黄平君长t,今敏,Onn分钟Zambon,玛丽亚·c·汉斯,特雷弗·t·奥彭肖,彼得·J。},标题={模式哮喘住院患者的全身和局部炎症与流感},体积= {54}= {4},elocation-id = {1900949} = {2019}, doi ={10.1183/13993003.00949 -2019},出版商={欧洲呼吸学会},文摘={背景哮喘患者与流感住院的风险,但这种倾向的原因是未知的。188bet官网地址研究的前瞻性观察研究成人PCR-confirmed流感在英国医院、11测量鼻腔、鼻咽和系统性免疫介质和遗传基因的表达。结果133年招生,40(30 \ %)以前哮喘;这是更多的女性(70 \ %和38.7 \ %,或3.69,95 \ % CI 1.67 {\ textendash} 8.18;p = 0.0012),需要减少机械通气(15和37.6 \ \ % %,卡方6.78;p = 0.0338),住院时间短(平均8.3和15.3天,p = 0.0333)比那些没有。在病人没有哮喘,严重的结果更频繁的在那些给予糖皮质激素(1.02或2.63,95 \ % CI {\ textendash} 6.96;p = 0.0466)或呈现\ >发病后4天(2.28或5.49,95 \ % CI {\ textendash} 14.03;p = 0.0002)。高危人群接种流感疫苗(包括哮喘)是由国家政策和低于预期的早期使用抗病毒药物是小于最优。团体之间的黏膜免疫反应是一样的。 Those with asthma had higher serum interferon (IFN)-α, but lower serum tumour necrosis factor, interleukin (IL)-5, IL-6, CXCL8, CXCL9, IL-10, IL-17 and CCL2 levels (all p\<0.05); both groups had similar serum IL-13, total IgE, periostin and blood eosinophil gene expression levels. Asthma diagnosis was unrelated to viral load, IFN-α, IFN-γ, IL-5 or IL-13 levels.Conclusions Asthma is common in those hospitalised with influenza, but may not represent classical type 2-driven disease. Those admitted with influenza tend to be female with mild serum inflammatory responses, increased serum IFN-α levels and good clinical outcomes.Patients with asthma hospitalised with influenza are commonly female and lack classical type 2 nasal mucosal inflammation. They have good prognosis with enhanced type 1 interferon production and reduced systemic inflammation. http://bit.ly/2Ovzz7O}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/54/4/1900949}, eprint = {//www.qdcxjkg.com/content/54/4/1900949.full.pdf}, journal = {European Respiratory Journal} }