TY -的T1 -腔静脉回流和右心室肺动脉高血压的僵硬JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.00625 -2019欧元六世- 54 - 4 SP - 1900625 AU -马库斯,J·蒂姆•AU - Westerhof Berend e . AU - Groeneveldt,乔安妮·a . AU - Bogaard伤害1月非盟-德曼,Frances S. AU - Vonk Noordegraaf, Anton Y1 - 2019/10/01 UR - //www.qdcxjkg.com/content/54/4/1900625.abstract N2 -腔静脉回流是公认的肺动脉高压(PAH)右心室衰竭的临床标志。右心室收缩时三尖瓣反流或心房收缩时右心室舒张充盈受损可能导致回流。我们的目的是量化腔静脉的向前和向后流动，并确定肺动脉高压的主要原因。在62名PAH患者中，心脏磁共振测量提供了上下腔静脉容积流量(mL·s−1);流量的时间积分得到体积。“后向分数”定义为腔静脉内前后体积之比，用百分数表示。最大腔静脉回流时间以占心动周期的百分比表示。测定右心室容积和主动脉卒中容积。右心导管术显示右心室和右心房压。 Right ventricular end-diastolic stiffness was determined with the single-beat method.The median (interquartile range) backward fraction was 12% (3–24%) and it was >20% in 21 patients. Maximum backflow occurred at near 90% of the cardiac cycle, coinciding with atrial contraction. The backward fraction was associated with maximal right atrial pressure (Spearman's r=0.77), right ventricular end-diastolic stiffness (r=0.65) and right ventricular end-diastolic pressure (r=0.77), and was negatively associated with stroke volume (r= –0.61) (all p<0.001).Significant backward flow in the vena cava was observed in a large group of PAH patients and occurred mostly during atrial contraction as a consequence of impaired right ventricular filling due to right ventricular diastolic stiffness. The backward flow due to tricuspid regurgitation was of significance in only a small minority of patients.In 62 patients with pulmonary arterial hypertension, timing of maximal backflow in the vena cava was in late diastole, during the right atrial contraction. The amount of backflow was associated with right ventricular stiffness. Stroke volume was reduced. http://bit.ly/2Y8YKg8 ER -