Ty-Jour T1 - 循环粘附分子和亚临床间质性肺病：欧洲呼吸期刊Jo - Eur Respir J Do - 10.1183 / 13993003.00295-2019 VL - 54 IS - 3 SP - 1900295 Au - McGroder，Claire F. Au - 亚伦，嘉莉P. Au - Bielinski，Suzette J. Au - Kawut，Steven M. Au - Tracy，Russell P. Au - Raghu，Ganesh Au - Barr，R. Graham Au - Lederer，David J。Au - Podolanczuk，Anna J. Y1 - 2019/09/01 UR - //www.qdcxjkg.com/content/54/3/1900295.abstract n2 - 附着子可能导致间质性肺病的发育（ILD）已提出作为特发性肺纤维化的预后生物标志物。我们的目的是确定循环粘附分子可溶性细胞内粘附分子（SICAM）-1，可溶性血管细胞粘附分子（SVCAM）-1和P-SELETIN与社区住宅成年人的亚临床ILD相关。多民族研究在2000 - 2002年美国六年社区45-84岁的动脉粥样硬化，患者和女性。高衰减区域被定义为成像肺体积的百分比，随着心脏计算断层扫描（CT）的衰减-600--250 HU。全肺癌直观地评估间质肺异常。在个体的子集上进行肺活量测定法。判断ILD住院和死亡。在完全调整后分析中，较高水平的SICAM-1，SVCAM-1和P-SELETIN与更高的高衰减区域（2.94％，95％CI 1.80-4.07％; 1.24％，95％有关。CI 0.14-2.35％; 1.58％，95％CI 0.92-2.23％，更高的ILD住院速度（HR 1.36,95％CI 1.03-1.80; 1.40,95％CI 1.07-1.85;和2.03，95％CI 1.16-3.5）。 sICAM-1 was associated with greater prevalence of interstitial lung abnormalities (OR 1.39, 95% CI 1.13–1.71). sICAM-1 and P-selectin were associated with lower forced vital capacity (44 mL, 95% CI 12–76 mL and 29 mL, 95% CI 8–49 mL, respectively). sVCAM-1 and P-selectin were associated with increased risk of ILD death (HR 2.15, 95% CI 1.26–3.64 and 3.61, 95% CI 1.54–8.46, respectively).Higher levels of circulating sICAM-1, sVCAM-1 and P-selectin are independently associated with CT and spirometric measures of subclinical ILD, and increased rate of adjudicated ILD events among community-dwelling adults.In community-dwelling adults, adhesion molecules sICAM-1, sVCAM-1 and P-selectin are associated with CT measures of early lung injury, lower FVC, ILD hospitalisations and deaths, suggesting they may contribute to the development of pulmonary fibrosis http://bit.ly/2Xj0B6F ER -