Ty -jour t1-循环粘附分子和亚临床间质肺疾病：动脉粥样硬化的多族裔研究JF-欧洲呼吸杂志JO -EUR RESSIR J DO -10.1183/13993003.00295-20195.00295-2019 VL -54，Claire F. au -Aaron，Carrie P. au -Bielinski，Suzette J.Au -Kawut，Steven M. Au -Tracy，Tracy，Russell P. Au -Raghu，Ganesh，Ganesh Au -Barr，R。GrahamAu- Lederer，Lederer，David J David J。ILD）并已被提议为特发性肺纤维化中的预后生物标志物。我们的目的是确定循环粘附分子可溶性细胞内粘附分子（SICAM）-1，可溶性血管细胞粘附分子（SVCAM）-1和P-链染料是否与社区居住成人中的亚临界ILD相关。在2000 - 2002年，美国六个社区的动脉粥样硬化招募了45-84岁的男性和45-84岁的女性。较高的衰减区域定义为在心脏计算机断层扫描（CT）上衰减-600–250 HU成像的成像量百分比。在全肺CT上视觉评估间质肺异常。肺活量测定法在一个个体的一部分上进行。裁定ILD住院和死亡。在完全调整的分析中，SICAM-1，SVCAM-1和P-选择素的水平较高，与较高的衰减区域相关（2.94％，95％CI 1.80-4.07％； 1.24％； 1.24％，95％，95％CI 0.14–2.35％;和1.58％，95％CI 0.92–2.23％）和ILD住院率更高（HR 1.36，95％CI 1.03–1.80; 1.40; 1.40，95％CI 1.07-1.85;95％CI 1.16–3.5）。 sICAM-1 was associated with greater prevalence of interstitial lung abnormalities (OR 1.39, 95% CI 1.13–1.71). sICAM-1 and P-selectin were associated with lower forced vital capacity (44 mL, 95% CI 12–76 mL and 29 mL, 95% CI 8–49 mL, respectively). sVCAM-1 and P-selectin were associated with increased risk of ILD death (HR 2.15, 95% CI 1.26–3.64 and 3.61, 95% CI 1.54–8.46, respectively).Higher levels of circulating sICAM-1, sVCAM-1 and P-selectin are independently associated with CT and spirometric measures of subclinical ILD, and increased rate of adjudicated ILD events among community-dwelling adults.In community-dwelling adults, adhesion molecules sICAM-1, sVCAM-1 and P-selectin are associated with CT measures of early lung injury, lower FVC, ILD hospitalisations and deaths, suggesting they may contribute to the development of pulmonary fibrosis http://bit.ly/2Xj0B6F ER -