TY - JOUR T1 -循环粘附分子与亚临床间质性肺病:mesa研究摩根富林明-欧洲呼吸杂志》乔和J - 10.1183/13993003.00295 -2019欧元六世- 54 - 3 SP - 1900295 AU McGroder克莱尔·f . AU -亚伦,嘉莉p . AU - Bielinski苏泽特J . AU - Kawut Steven m . AU -特雷西,罗素p . AU -拉古,Ganesh AU -巴尔,r·格雷厄姆AU -莱德尔,David J. AU - Podolanczuk, Anna J. Y1 - 2019/09/01 UR - //www.qdcxjkg.com/content/54/3/1900295.abstract N2 -粘附分子可能有助于间质性肺疾病(ILD)的发展，并被认为是特发性肺纤维化的预后生物标志物。我们的目的是确定循环黏附分子可溶性细胞内黏附分子(sICAM)-1、可溶性血管细胞黏附分子(sVCAM)-1和p -选择素是否与社区居住成人的亚临床ILD有关。2000-2002年，多种族动脉粥样硬化研究招募了来自美国6个社区的45-84岁的男性和女性。高衰减区定义为在心脏计算机断层扫描(CT)上衰减- 600 - - 250 HU的成像肺体积的百分比。全肺CT目测肺间质异常。对一组个体进行肺活量测定。对患有肺病的住院和死亡作出裁决。在完全调整的分析中，较高水平的sICAM-1、sVCAM-1和p -选择素与更大的高衰减区相关(2.94%，95% CI 1.80-4.07%;1.24%， 95%置信区间0.14-2.35%; and 1.58%, 95% CI 0.92–2.23%, respectively), and greater rate of ILD hospitalisations (HR 1.36, 95% CI 1.03–1.80; 1.40, 95% CI 1.07–1.85; and 2.03, 95% CI 1.16–3.5, respectively). sICAM-1 was associated with greater prevalence of interstitial lung abnormalities (OR 1.39, 95% CI 1.13–1.71). sICAM-1 and P-selectin were associated with lower forced vital capacity (44 mL, 95% CI 12–76 mL and 29 mL, 95% CI 8–49 mL, respectively). sVCAM-1 and P-selectin were associated with increased risk of ILD death (HR 2.15, 95% CI 1.26–3.64 and 3.61, 95% CI 1.54–8.46, respectively).Higher levels of circulating sICAM-1, sVCAM-1 and P-selectin are independently associated with CT and spirometric measures of subclinical ILD, and increased rate of adjudicated ILD events among community-dwelling adults.In community-dwelling adults, adhesion molecules sICAM-1, sVCAM-1 and P-selectin are associated with CT measures of early lung injury, lower FVC, ILD hospitalisations and deaths, suggesting they may contribute to the development of pulmonary fibrosis http://bit.ly/2Xj0B6F ER -