@article {McGroder1900295, author = {McGroder, Claire F.和Aaron, Carrie P.和Bielinski, Suzette J.和Kawut, Steven M.和Tracy, Russell P.和Raghu, Ganesh和Barr, R. Graham和Lederer, David J.和Podolanczuk, Anna J.}，标题={循环粘附分子和亚临床间质性肺病:the multiethnic Study of Atherosclerosis}， volume = {54}， number = {3}， eloc- id = {1900295}， year = {2019}， doi = {10.1183/13993003.00295-2019}， publisher ={欧洲呼吸学会188bet官网地址}，粘连分子可能促进间质性肺病(ILD)的发展，并已被提出作为特发性肺纤维化的预后生物标志物。我们的目的是确定循环粘附分子可溶性细胞内粘附分子(sICAM)-1、可溶性血管细胞粘附分子(sVCAM)-1和p选择素是否与社区居民亚临床间质性肺病(ILD)有关。动脉粥样硬化的多种族研究于2000年在美国6个社区招募了年龄为45岁至84岁的男性和女性。高衰减区定义为心脏CT上衰减为-600{textendash}-250 HU的肺容积成像百分比。在全肺CT上观察肺间质异常。对一组个体进行了肺活量测定。对ILD住院和死亡进行了裁决。在完全调整的分析中，更高水平的sICAM-1、sVCAM-1和p -选择素与更高的高衰减区域相关(2.94\%，95\% CI 1.80{\textendash}4.07\%;1.24\%， 95\% CI 0.14{\textendash}2.35\%; and 1.58\%, 95\% CI 0.92{\textendash}2.23\%, respectively), and greater rate of ILD hospitalisations (HR 1.36, 95\% CI 1.03{\textendash}1.80; 1.40, 95\% CI 1.07{\textendash}1.85; and 2.03, 95\% CI 1.16{\textendash}3.5, respectively). sICAM-1 was associated with greater prevalence of interstitial lung abnormalities (OR 1.39, 95\% CI 1.13{\textendash}1.71). sICAM-1 and P-selectin were associated with lower forced vital capacity (44 mL, 95\% CI 12{\textendash}76 mL and 29 mL, 95\% CI 8{\textendash}49 mL, respectively). sVCAM-1 and P-selectin were associated with increased risk of ILD death (HR 2.15, 95\% CI 1.26{\textendash}3.64 and 3.61, 95\% CI 1.54{\textendash}8.46, respectively).Higher levels of circulating sICAM-1, sVCAM-1 and P-selectin are independently associated with CT and spirometric measures of subclinical ILD, and increased rate of adjudicated ILD events among community-dwelling adults.In community-dwelling adults, adhesion molecules sICAM-1, sVCAM-1 and P-selectin are associated with CT measures of early lung injury, lower FVC, ILD hospitalisations and deaths, suggesting they may contribute to the development of pulmonary fibrosis http://bit.ly/2Xj0B6F}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/54/3/1900295}, eprint = {//www.qdcxjkg.com/content/54/3/1900295.full.pdf}, journal = {European Respiratory Journal} }