TY - T1的累积效应说的吸烟ease burden and multimorbidity in adult-onset asthma JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01580-2018 VL - 54 IS - 3 SP - 1801580 AU - Tommola, Minna AU - Ilmarinen, Pinja AU - Tuomisto, Leena E. AU - Lehtimäki, Lauri AU - Niemelä, Onni AU - Nieminen, Pentti AU - Kankaanranta, Hannu Y1 - 2019/09/01 UR - //www.qdcxjkg.com/content/54/3/1801580.abstract N2 - Smokers and patients with heavy smoking history have usually been excluded from clinical studies of asthma. Thus, little is known about the impact of lifelong, cumulative tobacco exposure on asthma [1, 2]. The effect of smoking status (never-, ex- or current smoker) on disease burden of asthma has been more commonly recognised, but the impact of smoking history in pack-years has rarely been evaluated [3–6]. The impact of smoked pack-years has been previously reported only by few studies, showing adverse effects on lung function and asthma control [5, 7–10], whereas no significant differences in healthcare use, asthma-related questionnaires or medication use were reported among ex-smokers with severe asthma when patients were categorised based on smoked pack-years [4].Disease burden and multimorbidity in adult-onset asthma increase dose dependently with smoked pack-years http://bit.ly/311627jWe are grateful to research nurse Aino Sepponen for her input with data management. ER -