TY - JOUR T1 - CPAP治疗老年中度阻塞性睡眠呼吸暂停患者的作用:多中心随机对照试验JF -欧洲呼吸杂志JO - Eur Respir J DO - 10.1183/13993003.00518-2019 VL - 54 IS -2 SP - 1900518 AU - Ponce, Silvia AU - Pastor, Esther AU - Orosa, Belen AU - Oscullo, Grace AU - Catalán, Pablo AU - Martinez, Alfonso AU - Hernández, Luis AU - Muriel, Alfonso AU - Chiner, Eusebi AU - Martínez-García, Miguel Ángel A2 -，Y1 - 2019/08/01 UR - //www.qdcxjkg.com/content/54/2/1900518.abstract N2 -持续气道正压通气(CPAP)治疗老年非重度阻塞性睡眠呼吸暂停(OSA)患者的疗效存在争议。本研究的目的是评估CPAP治疗中度阻塞性睡眠呼吸窘迫综合征老年患者在临床、生活质量和神经认知方面的效果。这是一项开放标签、随机、多中心临床试验，纳入145例确诊中度阻塞性呼吸暂停(呼吸暂停-低通气指数15-29.9事件·h−1)的老年患者(≥70岁)，随机分为接受CPAP (n=73)或不接受CPAP (n=72) 3个月。主要终点是Epworth嗜睡量表(ESS)评分，次要终点包括生活质量(魁北克睡眠问卷(QSQ)领域评分)、睡眠相关症状、焦虑/抑郁的存在、基于办公室的血压测量和一些神经认知测试。根据意向治疗原则进行分析。平均±sd年龄74.9±4.6岁。CPAP组在ESS评分(调整后差异2.6分(95% CI 3.6-1.6)上有更大的改善;在某些睡眠相关症状和QSQ问卷的某些维度(夜间症状:- 0.7分(95% CI - 0.3 - - 1.0);0.0001和情绪:−0.4 (95% CI−0.1 -−0.7)点; p=0.023). However, CPAP did not demonstrate any effect on either neurocognitive tests (including anxiety and depression) or blood pressure levels. There was a positive correlation between the effect of CPAP and the improvement in ESS scores and quality of life domains.CPAP treatment resulted in a significant improvement in diurnal hypersomnia and some sleep-related symptoms and quality of life domains in elderly patients with moderate OSA.CPAP treatment improves diurnal hypersomnia and some sleep-related symptoms and quality of life in elderly patients with moderate obstructive sleep apnoea http://bit.ly/2EvjSGn ER -