@文章{Ponce1900518，作者= {Ponce, Silvia和Pastor, Esther和Orosa, Belen和Oscullo, Grace和Catal{\'a}n, Pablo和Martinez, Alfonso和Hern{\'a}ndez, Luis和Muriel, Alfonso和Chiner, Eusebi和Mart{\' i}nez-Garc{\' i}a, Miguel {\'a} ngel}，编辑={，}，标题= {CPAP治疗在老年中度阻塞性睡眠呼吸暂停患者中的作用:多中心随机对照试验}，体积={54}，编号={2}，位置-id ={1900518}，年份= {2019}，doi ={10.1183/13993003.00518-2019}，出版商={欧洲呼吸学会}，摘要={持续气道正压(CPAP)治疗老年非重度阻塞性睡眠呼吸暂停(OSA)患者的疗效存在争议。188bet官网地址本研究的目的是评估CPAP治疗中度阻塞性睡眠呼吸窘迫综合征老年患者在临床、生活质量和神经认知方面的效果。这是一项开放标签、随机、多中心临床试验，共145例老年患者(>=70岁)确诊中度OSA(呼吸暂停{\textendash}低通气指数15{\textendash}29.9个事件{\textperiodcentered}h-1)，随机分为接受CPAP (n=73)或不接受CPAP (n=72) 3个月。主要终点是Epworth嗜睡量表(ESS)评分，次要终点包括生活质量(魁北克睡眠问卷(QSQ)领域评分)、睡眠相关症状、焦虑/抑郁的存在、基于办公室的血压测量和一些神经认知测试。根据意向治疗原则进行分析。平均{\textpm}sd年龄为74.9{\textpm}4.6岁。CPAP组在ESS评分上取得了更大的改善(调整差2.6分(95% CI 3.6{\textendash}1.6);在某些睡眠相关症状和QSQ问卷的某些维度(夜间症状:-0.7 (95% CI -0.3{\textendash}-1.0)分;p\<0.0001和情绪:-0.4 (95\% CI -0.1{\textendash}-0.7)点;p = 0.023)。 However, CPAP did not demonstrate any effect on either neurocognitive tests (including anxiety and depression) or blood pressure levels. There was a positive correlation between the effect of CPAP and the improvement in ESS scores and quality of life domains.CPAP treatment resulted in a significant improvement in diurnal hypersomnia and some sleep-related symptoms and quality of life domains in elderly patients with moderate OSA.CPAP treatment improves diurnal hypersomnia and some sleep-related symptoms and quality of life in elderly patients with moderate obstructive sleep apnoea http://bit.ly/2EvjSGn}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/54/2/1900518}, eprint = {//www.qdcxjkg.com/content/54/2/1900518.full.pdf}, journal = {European Respiratory Journal} }