TY - T1的儿童呼吸道微生物群newly diagnosed with bronchiectasis largely retains its diversity JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00704-2019 VL - 54 IS - 2 SP - 1900704 AU - Pillarisetti, Naveen AU - Broderick, David AU - Ainsworth, Alana AU - Mulholland, Anna AU - Wagner Mackenzie, Brett AU - Middleton, Danielle AU - Byrnes, Catherine A. AU - Taylor, Michael W. Y1 - 2019/08/01 UR - //www.qdcxjkg.com/content/54/2/1900704.abstract N2 - There is a great deal of interest in the airway microbiota, its diversity and the role of specific microbial taxa in the pathophysiology of lung disease [1]. Non-cystic fibrosis bronchiectasis is a significant public health problem in many countries, including New Zealand, where prevalence is high and morbidity and mortality are substantial [2–4]. A role for bacteria in the pathophysiology of bronchiectasis is widely accepted but poorly characterised due to inherent difficulties with lower airway sampling, especially in young children. Culture-based studies demonstrate associations with Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae in children [2, 5], and Pseudomonas aeruginosa in adults and those with severe disease [6, 7]. Culture-independent methods have revealed complex airway microbial communities with differences between children and adults with bronchiectasis, and between adults with cystic fibrosis and bronchiectasis [8].Young children diagnosed with bronchiectasis have a lower airway microbiota that is highly diverse and very similar to healthy controls. Haemophilus, Moraxella, Neisseria and Streptococcus are the most abundant operational taxonomic units identified. http://bit.ly/2SkqRrqWe are very grateful to the children and parents who participated in the study. We also acknowledge the support of the anaesthesia team, respiratory team, operating theatre and support staff of Starship Children's Hospital and the Lab Plus services. We would like to thank our funding bodies: the Athlae Lyon Starship Research Trust, A+ Trust and Starship Foundation. ER -