TY - JOUR T1 - 供体的人类白细胞抗原-G的单核苷酸多态性与后肺移植死亡率JF相关联 - 欧洲呼吸杂志JO - 欧洲呼吸j执行 - 10.1183 / 13993003.02126-2018 VL - 54 - 2 SP - 1802126 AU -Lazarte，朱丽叶AU - 马，金AU - 马蒂奴，泰雷扎AU - 利维，丽然AU - 克莱门特，威廉AU - 怀特，马修AU - Pelling的，雅各布AU - 关，刘泽洪AU - 阿扎德，Sassan AU - Tikkanen，尤西非盟 -饶，维韦克AU - 汤姆林森，乔治AU - 德尔加多，迭戈AU - Keshavjee，Shaf AU - Juvet，斯蒂芬C. Y1 - 2019年8月1日UR - //www.qdcxjkg.com/content/54/2/1802126.abstract N2 - 人白细胞抗原（HLA）-G是一种非经典的HLA抑制免疫应答。其表达由单核苷酸多态性（SNP），其与移植结果相关修改。我们的目的是探讨供受者HLA-G的单核苷酸多态性与肺癌transplantation.In这种单中心研究后慢性肺移植物功能障碍（层叠）和死亡率之间的关系，我们在连续345个受援国和捐助国297调查11 HLA-G的SNP第一双侧肺移植。多变量Cox比例风险模型评估死亡和CLAD单核苷酸多态性的关联。Transbronchial biopsies (TBBx) and bronchoalveolar lavage (BAL) samples were examined using quantitative PCR, ELISA and immunofluorescence.Over a median of 4.75 years, 142 patients (41%) developed CLAD; 170 (49%) died. Multivariable analysis revealed donor SNP +3142 (GG+CG versus CC) was associated with increased mortality (hazard ratio 1.78, 95% CI 1.12–2.84; p=0.015). In contrast, five donor SNPs, -201(CC), -716(TT), -56(CC), G*01:03(AA) and 14 bp INDEL, conferred reduced mortality risk. Specific donor–recipient SNP pairings reduced CLAD risk. Predominantly epithelial HLA-G expression was observed on TBBx without rejection. Soluble HLA-G was present in higher concentrations in the BAL samples of patients who later developed CLAD.Specific donor SNPs were associated with mortality risk after lung transplantation, while certain donor–recipient SNP pairings modulated CLAD risk. TBBx demonstrated predominantly epithelial, and therefore presumably donor-derived, HLA-G expression in keeping with these observations. This study is the first to demonstrate an effect of donor HLA-G SNPs on lung transplantation outcome.This largest-ever study on HLA-G SNPs and their relationship to transplant outcomes recognises the role of lung donor HLA-G SNPs on allograft HLA-G expression and outcomes post lung transplantation, a factor previously ignored http://bit.ly/2VZURhm ER -