PT -期刊文章盟Lazarte朱丽叶AU - Ma,金盟——Martinu,特丽莎AU -利维,Liran AU -克里门,威廉AU -白色,马修AU -佩林,雅各AU -关,Zehong盟——自由,Sassan盟——Tikkanen Jussi盟——饶,Vivek盟——汤姆林森,乔治AU -德尔珈朵,迭戈盟——Keshavjee井非盟- Juvet,斯蒂芬·c·TI -供体人类白细胞antigen-G单核苷酸多态性与post-lung移植相关死亡率援助- 10.1183/13993003.02126 -2018 DP - 2019年8月01 TA -欧洲呼吸杂志》第六PG - 1802126 - 54 IP - 2 4099 - //www.qdcxjkg.com/content/54/2/1802126.short 4100 - //www.qdcxjkg.com/content/54/2/1802126.full所以欧元和J2019 8月01;AB -人白细胞抗原(HLA)- g是一种抑制免疫反应的非经典HLA。其表达被与移植结果相关的单核苷酸多态性(SNPs)修饰。我们的目的是研究供受体HLA-G SNPs与慢性肺移植功能障碍(CLAD)和肺移植术后死亡率之间的关系。在这项单中心研究中，我们检查了345例连续的HLA-G SNPs受体和297例首次双侧肺移植供体。多变量Cox比例风险模型评估了snp与死亡和复盖层之间的关系。经支气管活检(TBBx)和支气管肺泡灌洗(BAL)标本采用定量PCR、ELISA和免疫荧光检测。在平均4.75年的时间里，142名患者(41%)出现了包衣;170人(49%)死亡。多变量分析显示，供体SNP +3142 (GG+CG vs CC)与死亡率增加相关(危险比1.78,95% CI 1.12-2.84;p = 0.015)。 In contrast, five donor SNPs, -201(CC), -716(TT), -56(CC), G*01:03(AA) and 14 bp INDEL, conferred reduced mortality risk. Specific donor–recipient SNP pairings reduced CLAD risk. Predominantly epithelial HLA-G expression was observed on TBBx without rejection. Soluble HLA-G was present in higher concentrations in the BAL samples of patients who later developed CLAD.Specific donor SNPs were associated with mortality risk after lung transplantation, while certain donor–recipient SNP pairings modulated CLAD risk. TBBx demonstrated predominantly epithelial, and therefore presumably donor-derived, HLA-G expression in keeping with these observations. This study is the first to demonstrate an effect of donor HLA-G SNPs on lung transplantation outcome.This largest-ever study on HLA-G SNPs and their relationship to transplant outcomes recognises the role of lung donor HLA-G SNPs on allograft HLA-G expression and outcomes post lung transplantation, a factor previously ignored http://bit.ly/2VZURhm