作者@article {Lazarte1802126 = {Lazarte,朱丽叶和马,金和Martinu,特丽莎和征税,Liran和Klement,威廉和白色,马修和佩林,雅各布和关,Zehong与自由,Sassan Tikkanen,总裁,饶,Vivek汤姆林森,乔治和德尔珈朵,迭戈和Keshavjee井和Juvet,斯蒂芬·C。},标题={捐赠者人类白细胞antigen-G单核苷酸多态性与post-lung移植相关死亡率},体积= {54}= {2},elocation-id = {1802126} = {2019}, doi ={10.1183/13993003.02126 -2018},出版商={欧洲呼吸学会},文摘={人类白细胞抗原(HLA) - g是一种非经典的HLA,抑制免疫反应。188bet官网地址其表达被与移植结果相关的单核苷酸多态性(SNPs)修饰。我们的目的是研究供受体HLA-G SNPs与慢性肺移植功能障碍(CLAD)和肺移植术后死亡率之间的关系。在这项单中心研究中，我们检测了345例连续受者和297例首次双侧肺移植供者的11个HLA-G SNPs。多变量Cox比例风险模型评估了snp与死亡和复盖层之间的关系。经支气管活检(TBBx)和支气管肺泡灌洗(BAL)标本采用定量PCR、ELISA和免疫荧光检测。在平均4.75年的时间里，142~患者(41%)出现了包衣;170(49 \ %)死了。多变量分析显示，供体SNP +3142 (GG+CG vs CC)与死亡率增加相关(危险比为1.78,95% CI 1.12{textendash}2.84;p = 0.015)。相比之下，5个供体SNPs， -201(CC)， -716(TT)， -56(CC)， G*01:03(AA)和14 bp INDEL，降低了死亡风险。 Specific donor{\textendash}recipient SNP pairings reduced CLAD risk. Predominantly epithelial HLA-G expression was observed on TBBx without rejection. Soluble HLA-G was present in higher concentrations in the BAL samples of patients who later developed CLAD.Specific donor SNPs were associated with mortality risk after lung transplantation, while certain donor{\textendash}recipient SNP pairings modulated CLAD risk. TBBx demonstrated predominantly epithelial, and therefore presumably donor-derived, HLA-G expression in keeping with these observations. This study is the first to demonstrate an effect of donor HLA-G SNPs on lung transplantation outcome.This largest-ever study on HLA-G SNPs and their relationship to transplant outcomes recognises the role of lung donor HLA-G SNPs on allograft HLA-G expression and outcomes post lung transplantation, a factor previously ignored http://bit.ly/2VZURhm}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/54/2/1802126}, eprint = {//www.qdcxjkg.com/content/54/2/1802126.full.pdf}, journal = {European Respiratory Journal} }