TY - JOUR T1 -居家氧疗对肺动脉或慢性血栓栓塞性肺动脉高压患者运动能力和生活质量的影响:随机、安慰剂对照试验JF -欧洲呼吸杂志》乔欧元和J - 10.1183/13993003.002762019六世54是- 2 SP - 1900276 AU -乌尔里希,西尔维亚AU - sax,斯蒂芬妮AU - Hasler)伊丽莎白d . AU -施瓦兹,以斯帖即非盟-施耐德,西蒙•r . AU - Furian迈克尔AU -巴德,帕特里克·r . AU - Lichtblau莫娜盟——布洛赫康拉德·e·Y1 - 2019/08/01 UR - //www.qdcxjkg.com/content/54/2/1900276.abstract N2 -我们调查研究问题是否住处的氧疗法(DOXT)提高运动能力和生活质量的患者的肺动脉或远端慢性血栓栓塞肺动脉高压(PAH / CTEPH)出现轻微的休息低氧血症和运动诱导的氧去饱和。材料和方法30例肺动脉高压/CTEPH患者，平均±sd年龄60±15岁，肺动脉压力39±11 mmHg，脉搏血氧仪测量的静息动脉氧饱和度(SpO2)≥90%，6分钟步行试验时SpO2下降≥4%，肺动脉高压靶向药物治疗，在一项双盲交叉方案中，受试者随机接受DOXT和安慰剂(环境空气)治疗，每组5周以上，夜间和白天休息时经鼻插管，剂量为3 L·min - 1。治疗周期以2周洗脱期为间隔。共同主要结果是治疗期间6分钟步行距离(6MWD，呼吸周围空气)的变化和36项简短医疗结局问卷的身体功能量表的变化。结果DOXT使6MWD从基线478±113 m增加了19 (6-32)m (95% CI)，身体功能从52±29增加了4(0-8)分。与安慰剂相对应的变化是6MWD中1(−11-13)m和−2(−6-2)点的身体功能。治疗之间变化的差异为6MWD 18 (1-35) m (p=0.042)，身体功能6(1-11)分(p=0.029)。 DOXT significantly improved the New York Heart Association functional class versus placebo.Answer to the question This first randomised trial in PAH/CTEPH patients with exercise-induced hypoxaemia demonstrates that DOXT improves exercise capacity, quality of life and functional class. The results support large long-term randomised trials of DOXT in PAH/CTEPH.Domiciliary oxygen therapy improves 6-min walk distance and quality of life in patients with precapillary pulmonary hypertension who desaturate during exercise, and should thus be considered as an adjunct to medical therapy http://bit.ly/2M8H4iq ER -