RT期刊文章SR电子severi T1疾病ty and clinical outcomes of community-acquired pneumonia caused by non-influenza respiratory viruses in adults: a multicentre prospective registry study from the CAP-China Network JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1802406 DO 10.1183/13993003.02406-2018 VO 54 IS 2 A1 Zhou, Fei A1 Wang, Yimin A1 Liu, Yingmei A1 Liu, Xuedong A1 Gu, Li A1 Zhang, Xiaoju A1 Pu, Zenghui A1 Yang, Guoru A1 Liu, Bo A1 Nie, Qingrong A1 Xue, Bing A1 Feng, Jing A1 Guo, Qiang A1 Liu, Jianhua A1 Fan, Hong A1 Chen, Jin A1 Zhang, Yongxiang A1 Xu, Zhenyang A1 Pang, Min A1 Chen, Yu A1 Nie, Xiuhong A1 Cai, Zhigang A1 Xu, Jinfu A1 Peng, Kun A1 Li, Xiangxin A1 Xiang, Pingchao A1 Zhang, Zuoqing A1 Jiang, Shujuan A1 Su, Xin A1 Zhang, Jie A1 Li, Yanming A1 Jin, Xiuhong A1 Jiang, Rongmeng A1 Dong, Jianping A1 Song, Yuanlin A1 Zhou, Hong A1 Wang, Chen A1 Cao, Bin A1 , YR 2019 UL //www.qdcxjkg.com/content/54/2/1802406.abstract AB Although broad knowledge of influenza viral pneumonia has been established, the significance of non-influenza respiratory viruses in community-acquired pneumonia (CAP) and their impact on clinical outcomes remains unclear, especially in the non-immunocompromised adult population.Hospitalised immunocompetent patients with CAP were prospectively recruited from 34 hospitals in mainland China. Respiratory viruses were detected by molecular methods. Comparisons were conducted between influenza and non-influenza viral infection groups.In total, 915 out of 2336 adult patients with viral infection were enrolled in the analysis, with influenza virus (28.4%) the most frequently detected virus, followed by respiratory syncytial virus (3.6%), adenovirus (3.3%), human coronavirus (3.0%), parainfluenza virus (2.2%), human rhinovirus (1.8%) and human metapneumovirus (1.5%). Non-influenza viral infections accounted for 27.4% of viral pneumonia. Consolidation was more frequently observed in patients with adenovirus infection. The occurrence of complications such as sepsis (40.1% versus 39.6%; p=0.890) and hypoxaemia (40.1% versus 37.2%; p=0.449) during hospitalisation in the influenza viral infection group did not differ from that of the non-influenza viral infection group. Compared with influenza virus infection, the multivariable adjusted odds ratios of CURB-65 (confusion, urea >7 mmol·L−1, respiratory rate ≥30 breaths·min−1, blood pressure <90 mmHg (systolic) or ≤60 mmHg (diastolic), age ≥65 years) ≥3, arterial oxygen tension/inspiratory oxygen fraction <200 mmHg, and occurrence of sepsis and hypoxaemia for non-influenza respiratory virus infection were 0.87 (95% CI 0.26–2.84), 0.72 (95% CI 0.26–1.98), 1.00 (95% CI 0.63–1.58) and 1.05 (95% CI 0.66–1.65), respectively. The hazard ratio of 90-day mortality was 0.51 (95% CI 0.13–1.91).The high incidence of complications in non-influenza viral pneumonia and similar impact of non-influenza respiratory viruses relative to influenza virus on disease severity and outcomes suggest more attention should be given to CAP caused by non-influenza respiratory viruses.The high incidence of complications in non-influenza viral pneumonia and similar impact of non-influenza viruses relative to influenza virus on disease severity and outcomes suggest more attention should be given to CAP caused by non-influenza viruses http://bit.ly/2vRTvFK