TY -的T1 -微分肺组织基因表达ssion in males and females: implications for the susceptibility to develop COPD JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.02567-2017 VL - 54 IS - 1 SP - 1702567 AU - van den Berge, Maarten AU - Brandsma, Corry-Anke AU - Faiz, Alen AU - de Vries, Maaike AU - Rathnayake, Senani N.H. AU - Paré, Peter D. AU - Sin, Don D. AU - Bossé, Yohan AU - Laviolette, Michel AU - Nickle, David C. AU - Hao, Ke AU - Obeidat, Ma'en AU - Dragani, Tommaso A. AU - Colombo, Francesca AU - Timens, Wim AU - Postma, Dirkje S. Y1 - 2019/07/01 UR - //www.qdcxjkg.com/content/54/1/1702567.abstract N2 - Several studies have shown that sexual dimorphisms exist with respect to the susceptibility to smoking and the clinical presentation of chronic obstructive pulmonary disease (COPD) [1, 2]. Females with COPD have a faster annual decline in their forced expiratory volume in 1 s (FEV1) than males, even with a similar number of pack-years smoking [3, 4]. In addition, females develop a different type of COPD to males with less severe emphysematous destruction, but thicker small airway walls [5]. Several factors may contribute to the observed sex differences, e.g. smoking behaviour or exposures to other environmental agents [6, 7].Sex strongly affects the gene expression profile in lung tissue, and overall reflects the activity of different biological pathways that probably play a role in the susceptibility to develop COPD with smoking http://bit.ly/31drVkXThe authors would like to thank the staff at the Respiratory Health Network Tissue Bank of the FRQS for their valuable assistance with the lung eQTL dataset at Laval University. ER -