TY - T1的吸入型皮质类固醇激素减弱epithelial mesenchymal transition: implications for COPD and lung cancer prophylaxis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00778-2019 VL - 54 IS - 1 SP - 1900778 AU - Lu, Wenying AU - Sharma, Pawan AU - Eapen, Mathew Suji AU - Sohal, Sukhwinder Singh Y1 - 2019/07/01 UR - //www.qdcxjkg.com/content/54/1/1900778.abstract N2 - We read with great interest the recent original research article by Raymakers et al. [1] published in the European Respiratory Journal, regarding the beneficial effects of inhaled corticosteroids (ICS) in reducing the lung cancer risk in patients with chronic obstructive pulmonary disease (COPD). In their discussion, the authors mentioned that the mechanisms by which COPD is associated with an increased risk of lung cancer are not well-established. We do not know which mechanisms ICS inhibit for an appreciable reduction in lung cancer risk. This is a hugely important area and it is encouraging that leading respiratory journals are recognising this. Understanding these interactive mechanisms, we believe, is very important for better future translational approaches to establish early and preventive therapy [2, 3]. We would like to take this further and suggest a broader discussion on the latest findings in COPD pathology involving processes such as epithelial mesenchymal transition (EMT), angiogenesis and airway wall cellularity, and the effects of ICS on these aspects in COPD.Inhaled corticosteroids protect against lung cancer by inhibiting epithelial mesenchymal transition (EMT) in COPD http://bit.ly/2WG682I ER -