@Article {Cowman1900250，作者= {Cowman，Steven和Van Ingen，Jakko和Griffith，David E.和Loebinger，Michael R.}，标题= {非结核性分枝杆菌肺病}，体积= {54}，数字= {1}，Elocation-ID = {1900250}，年= {2019}，DOI = {10.1183 / 13993003.00250-2019}，出版商= {欧洲呼吸社会}，摘要= {188bet官网地址Nontuberous的分枝杆菌肺病（NTM-PD）是一个具有挑战性的感染越来越普遍，特别是在老年人身上，原因是未知的原因。虽然潜在的肺病是NTM-PD的良好危险因素，但它也可能发生在明显的健康的个体中。在该组中没有发现单一的常见遗传或免疫缺陷，可能对NTM-PD的宿主敏感性有助于与导致疾病发展的环境和微生物因子相互作用.NTM-PD的诊断依赖于临床，放射学和微生物效果的整合。NTM-PD的临床过程是异质的，一些患者保持稳定，无需治疗，其他患者也会产生与大量死亡率和发病率相关的难治性疾病。治疗方案基于孤立物种的身份，药物敏感性测试（对于一些药剂）和疾病的严重程度。通常需要多种抗生素，长时间，治疗经常耐受性。手术在选定病例中可能是有益的。 In some circumstances cure may not be attainable and there is a pressing need for better regimens to treat refractory and drug-resistant NTM-PD.This review summarises current knowledge on the epidemiology, aetiology and diagnosis of NTM-PD and discusses the treatment of two of the most clinically significant species, the M. avium and M.~abscessus complexes, with a focus on refractory disease and novel therapies.Despite significant advances the management of nontuberculous mycobacterial pulmonary disease remains challenging; new approaches are needed http://bit.ly/2WPDU8V}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/54/1/1900250}, eprint = {//www.qdcxjkg.com/content/54/1/1900250.full.pdf}, journal = {European Respiratory Journal} }