TY - JOUR T1 -高渗盐水吸入治疗非结核分枝杆菌性肺部疾病的疗效JF -欧洲呼吸杂志JO - Eur Respir J DO - 10.1183/13993003.02143-2018 VL - 54 IS - 1 SP - 1802143 AU - Huiberts, Anne AU - Zweijpfenning, Sanne M.H. AU - Pennings, Lian J. AU - Boeree, Martin J. AU - van Ingen, Jakko AU - Magis-Escurra, Cecile AU - Hoefsloot,Wouter Y1 - 2019/07/01 UR - //www.qdcxjkg.com/content/54/1/1802143.abstract N2 -非结核分枝杆菌肺病(NTM-PD)的治疗对临床医生和患者提出了挑战。治疗包括18-24个月的多药抗生素治疗,治愈率为50-70%[1]。治愈率取决于致病NTM的种类、药物敏感性和疾病表现;大环内酯耐药和纤维空洞病是治疗失败的危险因素。即使治疗被认为是成功的,复发或再次感染的风险也很高。此外,不良事件,如胃肠道不适,经常可见,偶尔需要停止治疗。对潜在肺部疾病的管理对于NTM-PD治疗的成功至关重要。由于吸入高渗盐水(HS)是安全的,并已在支气管扩张患者中显示出临床效果[2-4],我们已将吸入高渗盐水纳入我们当地的NTM治疗方案。在临床实践中,我们建议结节-支气管扩张病患者开始时,将HS吸入作为前3个月的唯一治疗方法,每天两次。 When patients tolerate HS and when there are no clinical signs of disease deterioration, we continue HS as the only treatment with close observation of possible disease progression. This clinical observation includes a high-resolution chest tomography, sputum or bronchoalveolar lavage mycobacterial cultures and pulmonary function tests.Patients with nontuberculous mycobacterial lung disease benefit from hypertonic saline inhalation http://bit.ly/2WQpYMz ER -