TY - T1的炎症和感染的累积效应对结构在早期的囊性纤维化肺病JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01771 -2018欧元六世- 54 - 1 SP - 1801771 AU -罗斯诺夫,蒂姆•AU - Mok l .克拉拉AU - Turkovic Lidija AU -贝瑞,卢克J . AU -狡猾的彼得·d . AU - Ranganathan Sarath盟——Tiddens伤害A.W.M. AU -棒,肺部炎症和感染是囊性纤维化(CF)患者肺部疾病的重要临床和预后标志物。然而，在幼儿中，它们是短暂的还是对呼吸健康有累积的长期影响，在很大程度上尚不清楚。我们的目的是确定他们的重复检测是否对结构性肺病有有害的影响。方法回顾性分析6岁以上支气管肺泡灌洗患者的临床资料。使用PRAGMA-CF (Perth-Rotterdam注释网格形态计量分析CF)方法确定CT上的结构性肺病(疾病%)。计数BAL中游离中性粒细胞弹性酶(NE)和感染的次数，以确定累积的BAL病史。线性混合模型分析，考虑了重复访问和调整年龄，以确定关联。结果265名儿童(683次扫描)被纳入分析，BAL病史包括1161次就诊。%的疾病与先前NE的数量显著相关(0.31,95% CI 0.09-0.54;p=0.007)但未感染(0.23,95% CI−0.01-0.47; p=0.060) detections. Reference equations were determined.Conclusions Pulmonary inflammation in surveillance BAL has a cumulative effect on structural lung disease extent, more so than infection. This provides a strong rationale for therapies aimed at reducing inflammation in young children.Pulmonary inflammation and infection have cumulative effects on structural lung disease in young children with CF. These observations underscore the importance of developing anti-inflammatory interventions for use in early life. http://bit.ly/2VRo8qv ER -