@article {Rosenow1801771作者={罗斯诺夫,蒂姆和Mok l .克拉拉和Turkovic Lidija和浆果,卢克j .和狡猾的彼得•d和Ranganathan Sarath Tiddens,伤害A.W.M.贴,斯蒂芬·M。},标题={炎症和感染的累积效应对结构在早期的囊性纤维化肺病},体积= {54}= {1},elocation-id = {1801771} = {2019}, doi ={10.1183/13993003.01771 -2018},出版商={欧洲呼吸学会},文摘={介绍肺部炎症和感染是重要的临床和预后的标志在囊性纤维化肺病(CF)。188bet官网地址然而,无论是在幼儿瞬态结果或累积,长期对呼吸健康的影响在很大程度上是未知的。我们旨在确定他们的重复检测有害影响结构性肺部疾病。方法所有患者\ < 6岁年度计算机断层扫描(CT)和支气管肺泡灌洗(BAL)包括在内。结构肺部疾病CT(\ %疾病)确定使用PRAGMA-CF(珀斯{\ textendash}鹿特丹注释CF)网格的形态学分析方法。免费的次数中性粒细胞弹性蛋白酶(NE)和感染BAL中发现计算,来确定历史累积落下帷幕。线性混合模型分析,占重复访问和调整的时代,是用来确定关联。扫描结果265名儿童(683)包括用于分析,与矿山历史由1161人次。疾病\ %明显与之前的数量不相关(0.31,95 \ % CI 0.09 {\ textendash} 0.54;p = 0.007)但不感染(0.23,95 \ % CI -0.01 {\ textendash} 0.47; p=0.060) detections. Reference equations were determined.Conclusions Pulmonary inflammation in surveillance BAL has a cumulative effect on structural lung disease extent, more so than infection. This provides a strong rationale for therapies aimed at reducing inflammation in young children.Pulmonary inflammation and infection have cumulative effects on structural lung disease in young children with CF. These observations underscore the importance of developing anti-inflammatory interventions for use in early life. http://bit.ly/2VRo8qv}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/54/1/1801771}, eprint = {//www.qdcxjkg.com/content/54/1/1801771.full.pdf}, journal = {European Respiratory Journal} }