复合菌群泰的T1 -非结核分枝杆菌pulmonary disease and Aspergillus co-infection: Bonnie and Clyde? JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00117-2019 VL - 54 IS - 1 SP - 1900117 AU - Geurts, Kim AU - Zweijpfenning, Sanne M.H. AU - Pennings, Lian J. AU - Schildkraut, Jodie A. AU - Boeree, Martin J. AU - Magis-Escurra, Cecile AU - van der Lee, Henrich AU - Verweij, Paul E. AU - Hoefsloot, Wouter AU - van Ingen, Jakko Y1 - 2019/07/01 UR - //www.qdcxjkg.com/content/54/1/1900117.abstract N2 - Nontuberculous mycobacteria (NTM) cause difficult-to-treat opportunistic infections, most frequently of the lungs. Patients with chronic obstructive pulmonary diseases, cystic fibrosis or bronchiectasis are prone to NTM pulmonary disease (PD) and other opportunistic infections, including by Aspergillus fumigatus. Co-infections are difficult to identify as diagnostic criteria for NTM-PD and chronic pulmonary aspergillosis (CPA) overlap [1, 2]. The literature suggests that NTM and Aspergillus co-infections are associated with higher mortality [3]. Therefore, Aspergillus serology is part of NTM-PD diagnostic work up in our reference centre.40% of patients diagnosed with nontuberculous mycobacterial lung disease also meet diagnostic criteria for chronic pulmonary aspergillosis and Mycobacterium avium stimulates Aspergillus growth in vitro http://bit.ly/2JmLKk5 ER -