TY - T1的肠道模型cysti瀑样c fibrosis JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.02379-2018 VL - 54 IS - 1 SP - 1802379 AU - van Mourik, Peter AU - Beekman, Jeffrey M. AU - van der Ent, Cornelis K. Y1 - 2019/07/01 UR - //www.qdcxjkg.com/content/54/1/1802379.abstract N2 - Recent advances in adult stem cell biology have resulted in the development of organoid culture technologies using a variety of tissue sources such as intestine, lung and kidney [1]. Organoids are three-dimensional, multicellular structures that recapitulate tissue features of the parental organ and are usually grown from donor tissue fragments [1]. As organoids are functional expressions of individual genomes, these cultures are particularly useful to understand how genetic factors contribute to individual disease. As such, they are used to study hereditary diseases such as cystic fibrosis (CF), and more common diseases such as cancer where genetics can influence disease severity and drug efficacy [2, 3].CF can be studied using patient-specific intestinal organoids. CFTR protein function in intestinal organoids correlates with clinical disease severity and drug testing in organoids could aid in finding drugs for people with rare CFTR mutations. https://bit.ly/2GryRl0 ER -