PT -期刊文章AU -马丁内斯,莱昂纳多AU - Verma Renu AU - Croda,旗下胡里奥盟——Horsburgh c . Robert盟——沃尔特·凯瑟琳s . AU - Degner尼古拉斯AU - Middelkoop,克伦AU -科赫,阿纳斯塔西娅盟,何曼思Sabine AU -华纳,迪格比f . AU -木头,罗宾盟——Cobelens弗兰克AU -安德鲁斯,杰森·r·TI -检测结核分枝杆菌在环境中的生存和感染潜力:审查的证据和流行病学意义援助- 10.1183/13993003.02302 -2018 DP - 2019年6月01 TA -欧洲呼吸杂志》第六PG - 1802302 - 53年IP - 6 4099 - //www.qdcxjkg.com/content/53/6/1802302.short 4100 - //www.qdcxjkg.com/content/53/6/1802302.full所以欧元和J2019 6月01;关于结核分枝杆菌的传播仍有许多未知。20世纪50年代的开创性实验研究表明,传染性结核病(TB)患者通过空气排出飞沫核是主要的传播途径。然而,这些发现并没有排除结核分枝杆菌传播的其他途径。我们回顾了从19世纪末到20世纪初的历史科学证据和当代关于环境中结核分枝杆菌存在、持久性和传染性的研究。我们发现实验和流行病学证据支持结核分枝杆菌在多种自然和建筑环境中存在和生存数月至数年,可能是在人类源污染之后。此外,一些研究利用豚鼠和小鼠模型证实了结核分枝杆菌在环境中的生存能力和毒性。大部分证据都是历史的; however, several recent studies have reported consistent findings of M. tuberculosis detection and viability in the environment using modern methods. Whether M. tuberculosis in environments represents an infectious threat to humans requires further investigation; this may represent an untapped source of data with which to further understand M. tuberculosis transmission. We discuss potential opportunities for harnessing these data to generate new insights into TB transmission in congregate settings.Although airborne transmission is accepted as the primary mechanistic route of Mycobacterium tuberculosis, there is a high-quality scientific evidence base supporting the presence, persistence and infectiousness of M. tuberculosis in the environment http://bit.ly/2VwoSnK