RT期刊文章SR电子T1实验动物过敏是可预防的现代研究设施摩根富林明欧洲呼吸杂志乔和J FD欧元欧洲呼吸学会SP 1900171 10.1183/13993003.00171 -2019签证官53是6 A1 Feary, Johanna r . A1斯科菲尔德,苏珊·J·A1 Canizales詹妮弗A1菲茨杰拉德188bet官网地址,伯纳黛特A1 Potts,詹姆斯·琼斯A1 Meinir A1天玺,保罗年2019 UL //www.qdcxjkg.com/content/53/6/1900171.abstract AB背景历史数据显示15%的实验动物工作者开发IgE敏化作用和10% (LAA)实验动物过敏的症状,包括职业性哮喘。单独通风笼(ivc)正在取代传统的开放的笼子;我们试图评估其影响LAA的发展。方法调查750例实验室动物工人和机载测量亩m 1(鼠标过敏原)水平在英国7机构。我们比较普遍的敏化作用小鼠蛋白质(通过特定的IgE化验或皮肤针刺试验)和与工作有关的过敏症状IVC-only和打开笼子单位。结果Full-shift亩m 1水平低于打开笼子在印度河流域文明单位(几何平均数为1.00 (95% CI 0.73 - -1.36)和8.35 (95% CI 6.97 - -9.95) ng·m−3;p < 0.001),但不同倍在印度河流域文明单位(几何平均范围0.33 - -4.12 ng·m−3)。主要分析数据从216名参与者≤3年暴露小鼠显示患病率较低的敏化作用在印度河流域文明单位与传统笼单位工作(2.4% (n = 2)和9.8% (n = 13);p = 0.052)。敏化作用在印度河流域文明单位从0%变化到12.5%;使用呼吸防护安装在印度河流域文明单位的不太常见的高患病率的敏化作用。 Work-related allergy symptoms were more frequently reported by mouse-sensitised individuals (46.7% versus 10.9%; p<0.001) and only by those working in open cage units.Conclusion In contemporary practice, LAA is now largely preventable with the use of IVC systems and the judicious use of appropriate respiratory protection.Laboratory animal allergy, an important form of occupational asthma, can be prevented in modern research units using a multifaceted approach including individually ventilated cages to contain aeroallergen exposure and careful use of respiratory protection http://ow.ly/r6dM30oj3Ij