AU - Feary, Johanna R. AU - Schofield, Susan J. AU - Canizales, Jennifer AU - Fitzgerald, Bernadette AU - Potts, James AU - Jones, Meinir AU - Cullinan，Paul TI -实验室动物过敏是可以在现代研究设施中预防的AID - 10.1183/13993003.00171-2019 DP -2019 6月01日TA -欧洲呼吸杂志PG - 1900171 VI - 53 IP - 6 4099 - //www.qdcxjkg.com/content/53/6/1900171.short 4100 - //www.qdcxjkg.com/content/53/6/1900171.full SO - Eur Respir J2019 01年6月;历史数据表明，15%的实验动物工作者出现IgE致敏，10%的实验动物过敏(LAA)症状，包括职业性哮喘。个别通风笼取代传统的露天笼;我们试图评估它们对LAA发展的影响。我们调查了750个实验动物工作者，并测量了7个英国机构的空气中Mus m1(小鼠过敏原)水平。我们比较了小鼠蛋白致敏(通过特异性IgE测定或皮肤点刺试验)的流行程度和与工作相关的过敏症状在仅ivc和开笼单元中的流行程度。结果下腔静脉全移位Mus m1水平低于开笼单位(几何均值1.00 (95% CI 0.73-1.36) vs 8.35 (95% CI 6.97-9.95) ng·m−3;p<0.001)，但在IVC单位之间变化8倍(几何平均范围为0.33-4.12 ng·m−3)。对216名与小鼠接触≤3年的参与者的数据进行初步分析后发现，与传统笼型单位相比，在IVC单位工作的人员的致敏率较低(2.4% (n=2) vs 9.8% (n=13);p = 0.052)。 Sensitisation in IVC units varied from 0% to 12.5%; the use of fitted respiratory protection was less common in IVC units where prevalence of sensitisation was higher. Work-related allergy symptoms were more frequently reported by mouse-sensitised individuals (46.7% versus 10.9%; p<0.001) and only by those working in open cage units.Conclusion In contemporary practice, LAA is now largely preventable with the use of IVC systems and the judicious use of appropriate respiratory protection.Laboratory animal allergy, an important form of occupational asthma, can be prevented in modern research units using a multifaceted approach including individually ventilated cages to contain aeroallergen exposure and careful use of respiratory protection http://ow.ly/r6dM30oj3Ij