作者@article {Shoemark1900303 = {Shoemark,阿米莉亚和斜面,艾琳和Carreto,路易斯·史密斯,亚历山大和Oriano、玛蒂娜·基尔,冬青r和佩雷亚,莉迪亚和章,Elisabet•艾伯特,莱昂纳多和维达尔,西尔维亚和莫菲特,凯利和Aliberti,斯特凡诺Sibila, Oriol和查尔莫斯,詹姆斯D。}、标题={医疗点中性粒细胞弹性蛋白酶活力测定确定了支气管扩张严重,呼吸道感染和风险~ ~恶化},体积= {53}= {6},elocation-id = {1900303} = {2019}, doi ={10.1183/13993003.00303 -2019},出版商={欧洲呼吸学会},文摘={介绍痰中性粒细胞弹性蛋白酶活动可以识别高危患者呼吸道感染和支气管扩张急性加重。188bet官网地址这种生物标志物在临床实践中的应用是有限的,因为没有即时测试是可用的。我们测试是否一个新颖的半定量侧流设备(中性粒细胞弹性蛋白酶气道试验棒{\ textendash} NEATstik {\ textregistered})可以根据严重程度,分层支气管扩张患者呼吸道感染和恶化的风险。方法稳定的支气管扩张患者的痰样本124参加英国和西班牙进行了测试使用NEATstik {\ textregistered},这分数从0(中性粒细胞弹性蛋白酶浓度\ < 8 g {\ textmu} {\ textperiodcentered} mL-1弹性蛋白酶活动)到10(最大可检测中性粒细胞弹性蛋白酶活动)。高嗜中性粒细胞弹性蛋白酶活动被视为NEATstik {\ textregistered} \ > 6年级。严重疾病,呼吸道感染痰培养和在过去12个月内发作,被记录了下来。一个独立的验证是在50个病人进行从米兰,意大利。测量和主要结果病人的平均年龄69岁,在1 s用力呼气量(FEV1) 69 \ %。高中性粒细胞弹性蛋白酶活性与使用支气管扩张支气管扩张严重恶化是相关联的严重性指数(p = 0.0007),残(p = 0.02)。 A high NEATstik{\textregistered} grade was associated with a significant increase in exacerbation frequency, incident rate ratio 2.75 (95\% CI 1.63{\textendash}4.64, p\<0.001). The median time to next exacerbation for patients with a NEATstik{\textregistered} grade \>6 was 103 days compared to 278 days. The hazard ratio was 2.59 (95\% CI 1.71{\textendash}3.94, p\<0.001). Results were confirmed in the independent validation cohort.Conclusions A novel lateral flow device provides assessment of neutrophil elastase activity from sputum in minutes and identifies patients at increasing risk of airway infection and future exacerbations.NEATstik{\textregistered}, a simple point-of-care semi-quantitative neutrophil elastase assay, can identify bronchiectasis patients with airway infection and patients at high risk of exacerbations over the subsequent 12 months http://bit.ly/2HL6OyK}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/53/6/1900303}, eprint = {//www.qdcxjkg.com/content/53/6/1900303.full.pdf}, journal = {European Respiratory Journal} }