TY -的T1 -对精密医学野马hiectasis: what is the role of neutrophilic elastase determination? JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.00765-2019 VL - 53 IS - 6 SP - 1900765 AU - Oscullo Yepez, Grace AU - Sierra-Párraga, Jesus María AU - Posadas Blazquez, Tomás AU - Martínez-García, Miguel Ángel Y1 - 2019/06/01 UR - //www.qdcxjkg.com/content/53/6/1900765.abstract N2 - The 21st century will mark the transition from disease-centred medicine to patient-centred medicine. Medicine will evolve from the consideration of just a few symptoms and signs, and a limited number of complementary tests used to define most diseases, to the realisation that diseases are heterogeneous and dynamic. This change of paradigm will also mean that the current use of just a tiny fraction of the information provided by complementary tests will become outdated, and will result in an optimisation of most, if not all, of these findings. For example, less than 1% of the valid information provided by computed tomography of the chest, the gold standard for bronchiectasis diagnosis, is currently used. In short, this century will be the era of research into the complexity of diseases and the individualisation of treatment, based on the principles underlying what is known as “precision medicine”. We may still seem a long way from achieving these objectives, but there is no doubt that the necessary tools have been developing in leaps and bounds. We now have the capacity to efficiently handle vast amounts of data (big data) and glean valid information from them via techniques based on artificial intelligence [1]. There have also been significant advances in “-omics” and the relationships between them (multi-omics) and system biology; this will surely lead to an improved genotypic, phenotypic and endotypic characterisation of disease and, therefore, a better identification of both specific therapeutic targets and the directions to be followed by future research [2]. All this makes the identification and measurement of different biological biomarkers a field of research with enormous potential.Biomarkers will have an important role in the diagnosis, prognosis and response to treatment in bronchiectasis during the transition towards precision medicine http://bit.ly/30swlUK ER -