TY - JOUR T1 -环境空气污染和肺血管体积的计算机断层摄影术:台面空气污染和肺部群组研究JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.02116 -2018欧元六世- 53 - 6 SP - 1802116 AU -亚伦,嘉莉p . AU -霍夫曼,埃里克·a . AU - Kawut Steven m . AU -奥斯汀,约翰•莫莱森盟——Budoff马修AU - Michos,艾琳·d·盟,欣克利Stukovsky凯伦AU - Sack, Coralynn盟——Szpiro亚当·a . AU -沃森,卡罗尔d . AU -考夫曼,乔尔·d . AU -巴尔R. Graham Y1 - 2019/06/01 UR - //www.qdcxjkg.com/content/53/6/1802116.abstract N2 -背景空气污染改变动物模型的肺小血管。在一项基于人群的研究中，我们假设长期的环境空气污染暴露与肺血管容量的差异有关。方法:在美国六个城市招募成人进行动脉粥样硬化的多种族研究。利用时空模型估算了个人长期暴露于环境中的黑碳、二氧化氮(NO2)、氮氧化物(NOx)、空气动力学截止直径为2.5 μm的颗粒物(PM2.5)和臭氧。2010-2012年，测量肺总血管容积为在无对比胸部计算机断层扫描(TPVVCT)上检测到的肺动脉和静脉体积，包括血管壁和腔内血容量。外周TPVVCT仅限于外周2cm，以分离小血管。线性回归调整人口统计学，人体测量学，吸烟，二手烟，肾功能和扫描仪制造商。结果3023名受试者的平均±sd年龄为69.3±9.3岁;46%是不吸烟者。平均暴露量为0.80 μg·m−3炭黑、14.6 ppb NO2和11.0 μg·m−3环境PM2.5。 Mean±sd peripheral TPVVCT was 79.2±18.2 cm3 and TPVVCT was 129.3±35.1 cm3. Greater black carbon exposure was associated with a larger peripheral TPVVCT, including after adjustment for city (mean difference 0.41 (95% CI 0.03–0.79) cm3 per interquartile range; p=0.036). Associations for peripheral TPVVCT with NO2 were similar but nonsignificant after city adjustment, while those for PM2.5 were of similar magnitude but nonsignificant after full adjustment. There were no associations for NOx or ozone, or between any pollutant and TPVVCT.Conclusions Long-term black carbon exposure was associated with a larger peripheral TPVVCT, suggesting diesel exhaust may contribute to remodelling of small pulmonary vessels in the general population.In this large population-based study, higher ambient exposure to black carbon was associated with a greater volume of peripheral pulmonary vessels measured on noncontrast CT, suggesting diesel exhaust may impact small vessel remodelling in the lung http://ow.ly/nAEY30o8co4 ER -