PT -期刊文章盟亚伦,嘉莉p . AU -霍夫曼,埃里克·a . AU - Kawut Steven m . AU -奥斯汀,约翰•莫莱森盟——Budoff马修AU - Michos,艾琳·d·盟,欣克利Stukovsky凯伦AU - Sack, Coralynn盟——Szpiro亚当·a . AU -沃森,卡罗尔d . AU -考夫曼,乔尔·d . AU -巴尔,r·格雷厄姆TI -环境空气污染和肺部血管体积在计算机断层扫描:台面空气污染和肺部群组研究援助- 10.1183/13993003.02116 -2018 DP - 2019年6月01 TA -欧洲呼吸杂志》第六PG - 1802116 - 53年IP - 6 4099 - //www.qdcxjkg.com/content/53/6/1802116.short 4100 - //www.qdcxjkg.com/content/53/6/1802116.full所以欧元和J2019 6月01;53 AB -空气污染背景改变小肺血管在动物模型。我们提出长期空气污染暴露会被关联到不同的肺血管数量在以人群为基础的研究。方法动脉粥样硬化多种族研究招募了成年人在六个美国城市。个性化长期暴露在周围的黑碳、二氧化氮(NO2),氮氧化物(NOx),颗粒物切断空气动力学直径50% & lt; 2.5μm (PM2.5)和臭氧利用时空模型估计。在2010 - 2012年,肺血管总量测定的体积可检测肺动脉和肺静脉,包括血管壁和腔的血容量,41胸部计算机断层扫描(TPVVCT)。外围TPVVCT仅限于周边2厘米孤立小血管。线性回归调整人口结构、人体测量学、吸烟、二手烟、肾功能和扫描仪制造商。结果均值±sd 3023名参与者的年龄为69.3±9.3年;46%是不吸烟者。的意思是曝光0.80μg·米−3黑碳,NO2十亿分之14.6和11.0μg·m−3环境PM2.5。平均数±标准差外围TPVVCT 79.2±18.2立方厘米,TPVVCT 129.3±35.1立方厘米。 Greater black carbon exposure was associated with a larger peripheral TPVVCT, including after adjustment for city (mean difference 0.41 (95% CI 0.03–0.79) cm3 per interquartile range; p=0.036). Associations for peripheral TPVVCT with NO2 were similar but nonsignificant after city adjustment, while those for PM2.5 were of similar magnitude but nonsignificant after full adjustment. There were no associations for NOx or ozone, or between any pollutant and TPVVCT.Conclusions Long-term black carbon exposure was associated with a larger peripheral TPVVCT, suggesting diesel exhaust may contribute to remodelling of small pulmonary vessels in the general population.In this large population-based study, higher ambient exposure to black carbon was associated with a greater volume of peripheral pulmonary vessels measured on noncontrast CT, suggesting diesel exhaust may impact small vessel remodelling in the lung http://ow.ly/nAEY30o8co4