TY - JOUR T1 -环境空气污染与计算机断层扫描肺部血管体积:台面空气污染和肺部群组研究JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.02116 -2018欧元六世- 53 - 6 SP - 1802116 AU -亚伦,嘉莉p . AU -霍夫曼,埃里克·a . AU - Kawut Steven m . AU -奥斯汀,约翰•莫莱森盟——Budoff马修AU - Michos,艾琳·d·盟,欣克利Stukovsky凯伦AU -袋,Coralynn AU - Szpiro, Adam A. AU - Watson, Karol D. AU - Kaufman, Joel D. AU - Barr, R. Graham Y1 - 2019/06/01 UR - //www.qdcxjkg.com/content/53/6/1802116.abstract N2 -背景空气污染改变动物模型的肺小血管。在一项以人群为基础的研究中，我们假设长期暴露于环境空气污染与肺血管容量的差异相关。方法多种族动脉粥样硬化研究招募了美国6个城市的成年人。利用时空模型估算了个人长期暴露于环境黑碳、二氧化氮(NO2)、氮氧化物(NOx)、空气动力学直径50%为2.5 μm的颗粒物(PM2.5)和臭氧的情况。2010-2012年，肺血管总容积为非对比胸部ct (TPVVCT)检测到的肺动脉、静脉容积，包括血管壁和管腔血容量。外周TPVVCT局限于外周2cm以分离较小的血管。线性回归调整人口统计学，人体测量学，吸烟，二手烟，肾功能和扫描仪制造商。结果3023名受试者的平均±sd年龄为69.3±9.3岁;46%是不吸烟者。平均暴露量为0.80 μg·m−3黑碳、14.6 ppb NO2和11.0 μg·m−3环境PM2.5。 Mean±sd peripheral TPVVCT was 79.2±18.2 cm3 and TPVVCT was 129.3±35.1 cm3. Greater black carbon exposure was associated with a larger peripheral TPVVCT, including after adjustment for city (mean difference 0.41 (95% CI 0.03–0.79) cm3 per interquartile range; p=0.036). Associations for peripheral TPVVCT with NO2 were similar but nonsignificant after city adjustment, while those for PM2.5 were of similar magnitude but nonsignificant after full adjustment. There were no associations for NOx or ozone, or between any pollutant and TPVVCT.Conclusions Long-term black carbon exposure was associated with a larger peripheral TPVVCT, suggesting diesel exhaust may contribute to remodelling of small pulmonary vessels in the general population.In this large population-based study, higher ambient exposure to black carbon was associated with a greater volume of peripheral pulmonary vessels measured on noncontrast CT, suggesting diesel exhaust may impact small vessel remodelling in the lung http://ow.ly/nAEY30o8co4 ER -