TY - JOUR T1 -交通暴露、空气污染和肺动脉高压的结果:英国队列研究分析JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01429 -2018欧元六世- 53 - 5 SP - 1801429 AU Sofianopoulou Eleni盟——Kaptoge Stephen盟——伯爵,Stefan盟——Hadinnapola查拉卡非盟,崔西Carmen m . AU -教堂,科林AU - Coghlan,格里非盟-吉布斯,J·西蒙·r . AU - Haimel马提亚盟——霍华德、卢克·s . AU -约翰逊,马丁AU -基利,大卫·g . AU -洛瑞·艾伦盟——Lordan詹姆斯AU -麦肯齐·罗斯,Robert v . AU -马丁,珍妮弗·m . AU - Moledina萨因非盟-纽汉姆,迈克尔AU -孔雀,安德鲁j . AU -价格,劳拉·c . AU -罗兹,Christopher j . AU - Suntharalingam杰盟——Swietlik,伊米莉亚m . AU - ToshnerMark R. AU - Wharton, John AU - Wilkins, Martin R. AU - Wort, Stephen J. AU - Pepke-Zaba, Joanna AU - Condliffe, Robin AU - Corris, Paul A. AU - Di Angelantonio, Emanuele AU - Provencher, Steeve AU - Morrell，虽然交通和空气污染暴露与多种疾病的死亡率增加相关，但其与疾病严重程度和肺动脉高压(PAH)结局的相关性仍不清楚。暴露于50%截止空气动力直径≤2.5 μm (PM2.5)的颗粒物中，对英国特发性和遗传性PAH国家队列研究中招募的301名特发性/遗传性PAH患者进行了二氧化氮(NO2)和交通相关空气污染的间接测量(到主干道的距离和住宅地址周围缓冲区内的道路长度)的估计。评估基线时与无移植生存期和肺血流动力学严重程度的相关性，调整先验定义的混杂变量。更高的PM2.5估计暴露与更高的死亡或肺移植风险相关(未调整危险比(HR) 2.68 (95% CI 1.11-6.47) / 3 μg·m−3;p = 0.028)。当调整潜在混杂变量(HR 4.38 (95% CI 1.44-13.36) / 3 μg·m−3; p=0.009). No associations were found between NO2 exposure or other traffic pollution indicators and transplant-free survival. Conversely, indirect measures of exposure to traffic-related air pollution within the 500–1000 m buffer zones correlated with the European Society of Cardiology/European Respiratory Society risk categories as well as pulmonary haemodynamics at baseline. This association was strongest for pulmonary vascular resistance.In idiopathic/heritable PAH, indirect measures of exposure to traffic-related air pollution were associated with disease severity at baseline, whereas higher PM2.5 exposure may independently predict shorter transplant-free survival.In idiopathic pulmonary arterial hypertension, exposure to indirect measures of traffic-related air pollution was associated with haemodynamic severity and ESC/ERS risk score at baseline, whereas exposure to PM2.5 was associated with long-term prognosis http://ow.ly/G8En30o3swc ER -