交通暴露、空气污染与肺动脉高压的预后:英国队列研究分析JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01429 -2018欧元六世- 53 - 5 SP - 1801429 AU Sofianopoulou Eleni盟——Kaptoge Stephen盟——伯爵,Stefan盟——Hadinnapola查拉卡非盟,崔西Carmen m . AU -教堂,科林AU - Coghlan,格里非盟-吉布斯,J·西蒙·r . AU - Haimel马提亚盟——霍华德、卢克·s . AU -约翰逊,马丁AU -基利,大卫·g . AU -洛瑞·艾伦AU - Lordan,詹姆斯AU -麦肯齐·罗斯,Robert v . AU -马丁,詹妮弗·m . AU - Moledina萨因非盟-纽汉姆,迈克尔AU -孔雀,安德鲁j . AU -价格,劳拉·c . AU -罗兹,Christopher j . AU - Suntharalingam杰盟——Swietlik,伊米莉亚m . AU - Toshner马克。r . AU -沃顿,约翰AU -威尔金斯,马丁·r . AU -麦芽汁,Stephen j . AU - Pepke-Zaba乔安娜盟——Condliffe罗宾盟——Corris Paul a . AU - Di Angelantonio,埃盟——Provencher吊杆非盟——莫雷尔,虽然交通和空气污染暴露与多种疾病的死亡率增加有关，但其与疾病严重程度和肺动脉高压(PAH)预后的关系尚不清楚。暴露在颗粒物切断空气动力学直径2.5≤50%μm (PM2.5)、二氧化氮(NO2)和间接的措施与交通有关的空气污染(距离主干道和长度缓冲区内的道路周围的住宅地址)估计301例特发性/遗传多环芳烃在英国招募国家队列研究特发性和遗传的多环芳烃。评估基线时无移植生存期和肺血流动力学严重程度的相关性，并根据预先定义的混杂变量进行调整。估计暴露PM2.5与高死亡风险或肺移植(未经调整的风险比(人力资源)2.68 (95% CI 1.11 - -6.47) / 3μg·m−3;p = 0.028)。这种联系仍然类似的调整后潜在的混杂变量(HR 4.38 (95% CI 1.44 - -13.36) / 3μg·m−3;p = 0.009)。 No associations were found between NO2 exposure or other traffic pollution indicators and transplant-free survival. Conversely, indirect measures of exposure to traffic-related air pollution within the 500–1000 m buffer zones correlated with the European Society of Cardiology/European Respiratory Society risk categories as well as pulmonary haemodynamics at baseline. This association was strongest for pulmonary vascular resistance.In idiopathic/heritable PAH, indirect measures of exposure to traffic-related air pollution were associated with disease severity at baseline, whereas higher PM2.5 exposure may independently predict shorter transplant-free survival.In idiopathic pulmonary arterial hypertension, exposure to indirect measures of traffic-related air pollution was associated with haemodynamic severity and ESC/ERS risk score at baseline, whereas exposure to PM2.5 was associated with long-term prognosis http://ow.ly/G8En30o3swc ER -