TY - JOUR T1 - 交通暴露，空气污染和结果在肺动脉高血压：英国队列研究分析JF - 欧洲呼吸杂志JO - 欧洲呼吸j执行 - 10.1183 / 13993003.01429-2018 VL - 53 - 5 SP - 1801429 AU -Sofianopoulou，叶莱妮AU - Kaptoge，欧锦棠 - 格拉夫，斯特凡AU - Hadinnapola，查拉卡AU - 特里西，卡门M. AU - 教堂，科林AU - 科格伦，格里非盟 - 吉布斯，J.西蒙R. AU - Haimel，马蒂亚斯AU- 霍华德，卢克S. AU - 约翰逊，马丁AU - 基利，大卫G. AU - 劳列，艾伦AU - Lordan，詹姆斯AU - 麦肯齐·罗斯，罗伯特V. AU - 马丁，珍妮弗M. AU - Moledina，沙欣AU -纽纳姆，欧丁玉 - 孔雀，安德鲁J. AU - 价格，劳拉C. AU - 罗得岛，克里斯托弗J. AU - Suntharalingam，周杰伦AU - Swietlik，艾米利亚M. AU - Toshner，马克河AU - 沃顿，约翰AU -威尔金斯，马丁R. AU - 草，史蒂芬·J AU - Pepke - 扎巴，乔安娜AU - Condliffe，罗宾AU - 科里斯，保罗A.非盟 - 迪Angelantonio，埃马努埃莱AU - 普罗文，吊杆AU - 莫雷尔，尼古拉斯·W. Y1- 2019年5月1日UR - //www.qdcxjkg.com/content/53/5/1801429.abstract N2 - 虽然交通和空气污染暴露在许多疾病与增加的死亡率相关，其与疾病严重程度相关联并outcomes in pulmonary arterial hypertension (PAH) remains unknown.Exposure to particulate matter with a 50% cut-off aerodynamic diameter ≤2.5 μm (PM2.5), nitrogen dioxide (NO2) and indirect measures of traffic-related air pollution (distance to main road and length of roads within buffer zones surrounding residential addresses) were estimated for 301 patients with idiopathic/heritable PAH recruited in the UK National Cohort Study of Idiopathic and Heritable PAH. Associations with transplant-free survival and pulmonary haemodynamic severity at baseline were assessed, adjusting for confounding variables defined a priori.Higher estimated exposure to PM2.5 was associated with higher risk of death or lung transplant (unadjusted hazard ratio (HR) 2.68 (95% CI 1.11–6.47) per 3 μg·m−3; p=0.028). This association remained similar when adjusted for potential confounding variables (HR 4.38 (95% CI 1.44–13.36) per 3 μg·m−3; p=0.009). No associations were found between NO2 exposure or other traffic pollution indicators and transplant-free survival. Conversely, indirect measures of exposure to traffic-related air pollution within the 500–1000 m buffer zones correlated with the European Society of Cardiology/European Respiratory Society risk categories as well as pulmonary haemodynamics at baseline. This association was strongest for pulmonary vascular resistance.In idiopathic/heritable PAH, indirect measures of exposure to traffic-related air pollution were associated with disease severity at baseline, whereas higher PM2.5 exposure may independently predict shorter transplant-free survival.In idiopathic pulmonary arterial hypertension, exposure to indirect measures of traffic-related air pollution was associated with haemodynamic severity and ESC/ERS risk score at baseline, whereas exposure to PM2.5 was associated with long-term prognosis http://ow.ly/G8En30o3swc ER -