PT -期刊文章盟汉利亚姆•m . AU - Rautela琳达盟——Berlowitz David j . AU -麦克唐纳,克里斯汀·f . AU -科里,詹妮弗·m·盟——人字起重架,妮可AU -曹国伟,卡罗琳AU -唐格,Fergal j . AU -霍华德,马克·e·TI -随机对照试验无创通气障碍滴定的援助- 10.1183/13993003.02118 -2018 DP - 2019年5月01 TA -欧洲呼吸杂志》第六PG - 1802118 - 53年的IP - 5 4099 - //www.qdcxjkg.com/content/53/5/1802118.short 4100 - //www.qdcxjkg.com/content/53/5/1802118.full所以欧元和J2019可能01;53 AB -无创通气(NIV)设置决定在清醒可能产生过程中(PVA)在睡眠中,导致睡眠失调和限制宽容。本研究调查是否和合滴定与多导睡眠图(PSG)与PVA和睡眠中断低于治疗滴定白天独自一人。首次治疗的个体称为和合是随机控制(白天滴定其次是虚假的障碍滴定)或者巴黎圣日耳曼(白天滴定其次是障碍滴定)组。主要在PSG结果PVA和觉醒指数10周。次要结果包括依从性、气体交换、症状和健康相关的生活质量(HRQoL)。总共60参与者随机。大多数(88.3%)有神经肌肉紊乱和呼吸肌肉无力,但小紊乱在白天动脉血液气体。PVA事件不太频繁的接受障碍滴定(中位数(四分位范围(差)):PSG 25.7(12 - 68) 41.0事件·h−1与控制(28 - 182)事件·h−1;p = 0.046),但微觉醒没有显著不同(中位数(差):PSG 11.4(9-19)微觉醒·h−1与控制14.6(11-19)微觉醒·h−1;p = 0.258)。 Overall adherence was not different except in those with poor early adherence (<4 h·day−1) who increased their use after polysomnographic titration (mean difference: PSG 95 (95% CI 29–161) min·day−1 versus control −23 (95% CI −86–39) min·day−1; p=0.01). Arterial carbon dioxide tension, somnolence and sleep quality improved in both groups. There were no differences in nocturnal gas exchange or overall measures of HRQoL.NIV titrated with PSG is associated with less PVA but not less sleep disruption when compared with therapy titrated during daytime alone.In a cohort comprised mostly of individuals with neuromuscular disorders, nocturnal noninvasive ventilation was associated with less patient–ventilator asynchrony and adherence was better when treatment was titrated during polysomnography http://ow.ly/xibR30nY8c7